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Título: | WRKY7, -11 and -17 transcription factors are modulators of the bZIP28 branch of the unfolded protein response during PAMP-triggered immunity in Arabidopsis thaliana |
Autor: | Arraño-Salinas, P.; Domínguez-Figueroa, José; Herrera-Vásquez, A.; Zavala, D.; Medina, Joaquín CSIC ORCID; Vicente-Carbajosa, Jesús; Meneses González, Cristina; Canessa, P.; Moreno, Adrian A.; Blanco-Herrera, F. | Palabras clave: | WRKY bZIP Unfolded protein response Flg22 Basal defense response |
Fecha de publicación: | 2018 | Editor: | Elsevier | Citación: | Plant Science 277: 242-250 (2018) | Resumen: | Plants must defend themselves against pathogens. The defense response requires greater protein synthesis, which generates endoplasmic reticulum (ER) stress, yet failure to attenuate this stress has detrimental effects. WRKY7/11/17 transcription factors (TFs) are negative regulators of immunity since mutants are more resistant to Pseudomonas syringae pv tomato (Pst) infection. Here, we reveal a connection between ER-stress and the molecular mechanisms underlying the wrky mutant phenotype. The bZIP28 TF upregulates ER-chaperone expression (BiP1/2, ERdj3B, and SDF2) upon exposure of Arabidopsis to a bacterial defense elicitor, flagellin 22 (Flg22). Also, the activation of ER-chaperones is more sustained in double and triple wrky mutants treated with Flg22, suggesting that WRKY7/11/17 TFs downregulate these genes. Moreover, wrky mutants accumulate more bZIP28 transcripts in response to Flg22, indicating that WRKY7/11/17 transcriptionally repress this TF. Using Arabidopsis protoplasts, we also demonstrate that WRKYs bind to the bZIP28 promoter via W-box elements. Additionally, triple wrky mutants are more resistant, whilst bzip28 mutants are more susceptible, to Pst infection. Finally, we postulate a model of PAMP-Triggered Immunity regulation, where Flg22 activates bZIP28-signaling inducing the expression of ER-stress genes, as well as WRKY7/11/17 expression, which in turn inhibits PTI by downregulating bZIP28, controlling physiological responses in the Arabidopsis-Pst interaction | URI: | http://hdl.handle.net/10261/290670 | DOI: | 10.1016/j.plantsci.2018.09.019 | ISSN: | 0168-9452 |
Aparece en las colecciones: | (INIA) Artículos |
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