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Título: | Progesterone effects on mouse sperm kinetics in conditions of viscosity |
Autor: | Pérez Cerezales, Serafín; López-Cardona, Ángela P.; Gutiérrez-Adán, Alfonso CSIC ORCID | Fecha de publicación: | 2016 | Editor: | Bioscientifica | Citación: | Reproduction 151: 501-507 (2016) | Resumen: | The spermatozoa delivered to the female genital tract need to swim towards the oocyte through viscous secretions. Once close to the oocyte, the spermatozoa are guided by a gradient of progesterone (P4 ) and other unknown chemoattractants via a process known as chemotaxis. Using polyvinylpyrrolidone to establish the conditions of viscosity, we examined the response of mouse spermatozoa to P4 . Herein, we show that in low-viscous media, P4 induces hyperactive-like motility whereby sperm show erratic trajectories and non-progressive movement. However, an opposite response is produced in viscous medium in that trajectories are linear and motility is more progressive and less erratic. Our observations provide a behavioural explanation for the chemotaxis of spermatozoa swimming under viscous conditions in a spatial gradient of the chemoattractant P4 . They also highlight the importance of using viscous solutions to mimic in vivo conditions when analysing sperm behaviour in response to any stimulus. © 2016 Society for Reproduction and Fertility. | URI: | http://hdl.handle.net/10261/291296 | DOI: | 10.1530/REP-15-0582 | ISSN: | 1470–1626 | E-ISSN: | 1741–7899 |
Aparece en las colecciones: | (INIA) Artículos |
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