Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/293220
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | Molecular characterization of three novel chemokine receptors in rainbow trout (Oncorhynchus mykiss) |
Autor: | Dixon, Brian; Luque, Alfonso; Abós, Beatriz CSIC; Castro, Rosario; González Torres, Lucia; Tafalla, Carolina CSIC ORCID | Palabras clave: | Chemokine Receptors Fish Trout |
Fecha de publicación: | 2013 | Editor: | Elsevier | Citación: | Fish and Shellfish Immunology 34(2): 641-651 (2013) | Resumen: | Chemokines signal through a family of seven-transmembrane domain G-coupled receptors in order to regulate both leukocyte mobilization and activate the recruited cells. Although many chemokines have been identified in rainbow trout (Oncorhynchus mykiss), only a few chemokine receptors have been reported to date. In this work, we have cloned three novel chemokine receptors in rainbow trout. One of these receptors seems to be a clear orthologue of CCR6, while the second one constitutes a novel CCR9 gene different from the previous CCR9 reported in this species. This gene, which we have designated as CCR9B, represents another lineage of fish CCR9 genes, not previously identified. Finally, a deeper phylogenetic analysis of the third novel chemokine receptor gene, which had been identified on the basis of sequence similarity to CCR3, constitutes a novel lineage of CCR receptors which has no equivalent in humans and that may be teleost-specific. We have designated this novel gene as CCR13, to avoid any possible ascription to mammalian genes. Further transcriptional studies revealed that CCR6 was constitutively transcribed in thymus, gills, hindgut and peripheral blood leukocytes (PBLs), while CCR9B was strongly transcribed in thymus and PBLs but also in spleen, gills, hindgut and brain at lower levels. CCR13, on the other hand, was strongly detected in spleen, head kidney and PBLs and faintly in thymus, gills, brain and gonad. The data provided constitutes a step forward the identification of novel chemokine receptors that may contribute to a future understanding of chemokine signalling in fish. © 2012 Elsevier Ltd. | URI: | http://hdl.handle.net/10261/293220 | DOI: | 10.1016/j.fsi.2012.12.003 | ISSN: | 1050-4648 |
Aparece en las colecciones: | (INIA) Artículos |
Mostrar el registro completo
CORE Recommender
SCOPUSTM
Citations
23
checked on 28-abr-2024
WEB OF SCIENCETM
Citations
20
checked on 22-feb-2024
Page view(s)
29
checked on 06-may-2024
Google ScholarTM
Check
Altmetric
Altmetric
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.