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Título: | Analysis of monoclonal antibodies reactive with the porcine CD4 antigen |
Autor: | Pescovitz, M. D.; Aasted, B.; Canals, A.; Domínguez, Javier; Sánchez-Vizcaíno, J. M.; Pospisil, R.; Trebichavsky, I.; Salmon, H.; Valpotic, I.; Davis, William; Arn, S.; Sachs, David H.; Lunney, J. K.; Zuckermann, F.; Weiland, E.; Saalmüller, A. | Fecha de publicación: | 1994 | Editor: | Elsevier | Citación: | Veterinary Immunology and Immunopathology 43(1-3): 233-236 (1994) | Resumen: | As result of the First International Swine CD Workshop, four monoclonal antibodies (mAb) (#002, 054, 118, and 127) clustered closely to the internal standard anti-porcine CD4 mAb, 74-12-4. To further characterize the relationship between these mAb, they were used in flow cytometry to inhibit binding of 74-12-4 to porcine lymphocytes. mAb #002 (74-12-4) and #054 (PT90) completely inhibited, while mAb #127 (10.2H2) and #118 (b38c6) partially inhibited (57% and 77% respectively), the binding of 74-12-4. Furthermore, none of the mAbs bound to a 74-12-4 negative strain of pigs. We conclude that the four mAb bind to the same, or a closely related, epitope on porcine lymphocytes. © 1994. | URI: | http://hdl.handle.net/10261/293712 | DOI: | 10.1016/0165-2427(94)90141-4 | ISSN: | 0165-2427 |
Aparece en las colecciones: | (INIA) Artículos |
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