Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/353846
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | A Multifunctionalized Potyvirus-Derived Nanoparticle That Targets and Internalizes into Cancer Cells |
Autor: | Truchado, Daniel A.; Juárez-Molina, María; Rincón, Sara; Zurita, Lucía; Tome-Amat, Jaime; Lorz, C.; Ponz Ascaso, Fernando | Palabras clave: | Turnip mosaic virus VLP Protein A Z domain Cetuximab Squamous cell carcinoma Viral nanoparticles |
Fecha de publicación: | 13-abr-2024 | Editor: | Multidisciplinary Digital Publishing Institute | Citación: | International Journal of Molecular Sciences 25(8): e4327 (2024) | Resumen: | Plant viral nanoparticles (VNPs) are attractive to nanomedicine researchers because of their safety, ease of production, resistance, and straightforward functionalization. In this paper, we developed and successfully purified a VNP derived from turnip mosaic virus (TuMV), a well-known plant pathogen, that exhibits a high affinity for immunoglobulins G (IgG) thanks to its functionalization with the Z domain of staphylococcal Protein A via gene fusion. We selected cetuximab as a model IgG to demonstrate the versatility of this novel TuMV VNP by developing a fluorescent nanoplatform to mark tumoral cells from the Cal33 line of a tongue squamous cell carcinoma. Using confocal microscopy, we observed that fluorescent VNP–cetuximab bound selectively to Cal33 and was internalized, revealing the potential of this nanotool in cancer research. | Descripción: | 15 Pág. | Versión del editor: | https://doi.org/10.3390/ijms25084327 | URI: | http://hdl.handle.net/10261/353846 | DOI: | 10.3390/ijms25084327 | ISSN: | 1661-6596 | E-ISSN: | 1422-0067 |
Aparece en las colecciones: | (INIA) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
A_Multifunctionalized_Potyvirus_Derived.pdf | artículo | 3,07 MB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
Page view(s)
9
checked on 27-may-2024
Download(s)
2
checked on 27-may-2024
Google ScholarTM
Check
Altmetric
Altmetric
Este item está licenciado bajo una Licencia Creative Commons