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Título: | The RNA binding protein Zfp36l1 is required for normal vascularisation and post-transcriptionally regulates VEGF expression |
Autor: | Bell, Sarah E.; Sánchez, María José CSIC ORCID CVN; Spasic-Boskovic, Olivera; Santalucía, Tomàs CSIC ORCID; Gambardella, Laure; Burton, Graham J.; Murphy, John J.; Norton, John D.; Clark, Andrew R.; Turner, Martin | Palabras clave: | Zfp36I1 VEGF Extraembryonic and intraembryonic vasculature Neovascularization Nuclear proteins Polyribosomes Vascular Endothelial Growth Factor A Mutations |
Fecha de publicación: | 29-sep-2006 | Editor: | Wiley-Liss | Citación: | Developmental Dynamics 235(11): 3144-3155 (2006) | Resumen: | The Zfp36l1 gene encodes a zinc finger-containing mRNA binding protein implicated in the posttranscriptional control of gene expression. Mouse embryos homozygous for a targeted mutation in the Zfp36l1 locus died mid-gestation and exhibited extraembryonic and intraembryonic vascular abnormalities and heart defects. In the developing placenta, there was a failure of the extraembryonic mesoderm to invaginate the trophoblast layer. The phenotype was associated with an elevated expression of vascular endothelial growth factor (VEGF)-A in the embryos and in embryonic fibroblasts cultured under conditions of both normoxia and hypoxia. VEGF-A overproduction by embryonic fibroblasts was not a consequence of changes in Vegf-a mRNA stability; instead, we observed enhanced association with polyribosomes, suggesting Zfp36l1 influences translational regulation. These data implicate Zfp36l1as a negative regulator of Vegf-a gene activity during development. | Descripción: | 12 páginas, 9 figuras, 1 tabla. | Versión del editor: | http://dx.doi.org/10.1002/dvdy.20949 | URI: | http://hdl.handle.net/10261/41396 | DOI: | 10.1002/dvdy.20949 | ISSN: | 1058-8388 | E-ISSN: | 1097-0177 |
Aparece en las colecciones: | (CABD) Artículos |
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