Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/45935COMPARTIR / EXPORTAR:
 SHARE
 CORE
BASE
|
|
| Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
| Título: | Bcl2 is not required for the development and maintenance of leukemia stem cells in mice |
Autor: | González-Herrero, Inés CSIC ORCID; Vicente-Dueñas, Carolina CSIC ORCID; Orfao, Alberto CSIC ORCID ; Flores, Teresa; Jiménez, Rafael; Cobaleda, César CSIC ORCID; Sánchez García, Isidro CSIC ORCID | Fecha de publicación: | 18-mar-2010 | Editor: | Oxford University Press | Citación: | Carcinogenesis 31(7): 1292-1297 (2010) | Resumen: | The existence of leukemia stem cells (LSCs) responsible for tumor maintenance has been firmly established. Therefore, therapeutic targeting of these LSCs may have a profound impact on cancer eradication. The anti-apoptotic protein Bcl2 has been proposed as a therapeutic target, but its role in LSC biology has not been investigated. In order to understand the role of Bcl2 in LSC generation and maintenance, we have taken advantage of our Sca1-BCRABLp210 mouse model of human chronic myeloid leukemia and bcl2 gene-targeted mice. This study provides genetic evidence that the inhibition of Bcl2 is not critical for the generation, selection or maintenance of the tumor initiating and maintaining cells in mice. | Versión del editor: | http://dx.doi.org/10.1093/carcin/bgq062 | URI: | http://hdl.handle.net/10261/45935 | DOI: | 10.1093/carcin/bgq062 | ISSN: | 0143-3334 |
| Aparece en las colecciones: | (IBMCC) Artículos (CBM) Artículos |
Ficheros en este ítem:
| Fichero | Descripción | Tamaño | Formato | |
|---|---|---|---|---|
| accesoRestringido.pdf | 15,38 kB | Adobe PDF |  Visualizar/Abrir |
CORE Recommender
PubMed Central
Citations
6
checked on 25-abr-2024
SCOPUSTM
Citations
7
checked on 23-abr-2024
WEB OF SCIENCETM
Citations
7
checked on 24-feb-2024
Page view(s)
384
checked on 23-abr-2024
Download(s)
121
checked on 23-abr-2024
Google ScholarTM
Check
Altmetric
Altmetric
Artículos relacionados:
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.