Differential expression of snoRNAs in oral squamous cell carcinomas: new potential diagnostic markers
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Título: | Differential expression of snoRNAs in oral squamous cell carcinomas: new potential diagnostic markers |
Autor/a: | Chamorro Petronacci, Cintia Micaela Pérez-Sayáns García, Mario Padín Iruegas, María Elena Marichalar Mendia, Xabier Gallas Torreira, Mercedes García García, Abel |
Centro/Departamento: | Universidade de Santiago de Compostela. Departamento de Cirurxía e Especialidades Médico-Cirúrxicas |
Palabras chave: | Oral cancer | Epigenetics | snoRNA | |
Data: | 2018-01-26 |
Editor: | Taylor & Francis |
Cita bibliográfica: | Chamorro-Petronacci, C., Perez-Sayáns, M., Padín-Iruegas, M., Marichalar-Mendia, X., Gallas-Torreira, M., & García García, A. (2018). Differential expression of snoRNAs in oral squamous cell carcinomas: new potential diagnostic markers. Journal Of Enzyme Inhibition And Medicinal Chemistry, 33(1), 424-427. doi: 10.1080/14756366.2018.1426574 |
Resumo: | Background: Small nucleolar RNAs (snoRNAs) are small non-coding RNA sequences whose most studied function is ribosome biogenesis. The altered expression of snoRNA is observed in tumoral processes such as breast cancer and multiple myeloma. However, we have not found any references to snoRNAs in oral squamous cell carcinomas (OSCC) in the literature at the time this article was written. Material and methods: We have analyzed snoRNA expression in frozen OSCC tissue samples and have compared them to healthy controls. RNA was extracted from a total of eight OSCC samples and eight control samples, measuring the differential expression of small RNAs with the Affymetrix® miRNA 4.1 Array Plate microarray platform. Results: Results were analyzed using the Transcriptome Analysis Console 3.0 (TAC) software. We obtained a total of 16 deregulated snoRNAs of which one was over expressed and 15 were under expressed. SnoRNAs expression was altered in OSCC and could serve as a diagnostic marker |
Versión do editor: | https://doi.org/10.1080/14756366.2018.1426574 |
URI: | http://hdl.handle.net/10347/17637 |
DOI: | 10.1080/14756366.2018.1426574 |
ISSN: | 1475-6366 |
E-ISSN: | 1475-6374 |
Dereitos: | © 2018 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited Atribución 4.0 Internacional |
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© 2018 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
© 2018 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited