Lichenoid areas may arise in early stages of proliferative verrucous leukoplakia: a long-term study of 34 patients
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Título: | Lichenoid areas may arise in early stages of proliferative verrucous leukoplakia: a long-term study of 34 patients |
Autor/a: | Barba Montero, Catalina Lorenzo Pouso, Alejandro Ismael Gándara Vila, Pilar Blanco Carrión, Andrés Marichalar Mendía, Xabier García García, Abel Pérez Sayáns, Mario |
Centro/Departamento: | Universidade de Santiago de Compostela. Departamento de Cirurxía e Especialidades Médico-Cirúrxicas |
Palabras chave: | Dysplasia | Malignant transformation | Oral lichen planus | Oral lichenoid lesions | Proliferative verrucous leukoplakia | |
Data: | 2022 |
Editor: | Wiley |
Cita bibliográfica: | Barba-Montero C, Lorenzo-Pouso AI,Gándara-Vila P, et al. Lichenoid areas may arise in early stagesof proliferative verrucous leukoplakia: A long-term study of 34patients.J Oral Pathol Med. 2022;51(6):573‐581. doi:10.1111/jop.13317 |
Resumo: | Background: Proliferative verrucous leukoplakia is considered an uncommon oral potentially malignant disorder with a high malignant transformation rate. The objective of this paper was to define its cancer incidence and related risk factors.: Method: A retrospective audit of 34 patients diagnosed with proliferative verrucous leukoplakia from a university-based unit, during the period from 1995 to 2019 was performed. The mean number of visits was 23 ± 18.6. The follow-up was divided into four-time intervals to evaluate the clinical presentation, number of lesions, dysplasia grade, and malignant transformation rate. Results: The majority of patients were females 29 (85.3%), with verrucous component (77.8%), with a gingival presentation (31.8%), and with a preceding lichenoid area (44.1%). Eleven patients (32.4%) were affected by oral cancer during the follow-up, developing a total of 15 carcinomas. The mean age of malignant transformation was 67.2 ± 12.9 years, particularly 8 ± 8.5 from the onset of the lesions. Warty forms presented a higher mean estimate for malignant transformation (15.2 years, 95% confidence interval 4.4–26 years) than nodular forms (1.9 years, 95% confidence interval 1.9–1.9) (p = 0.019). Patients with an initial proliferative verrucous leukoplakia diagnosis suffered a higher risk of malignancy, particularly 15.55 times (95% confidence interval 1.69–143.17; p = 0.015) than those who did present a preceding area with lichenoid morphology. Conclusion: Proliferative verrucous leukoplakia presented a high malignant transformation rate and sometimes displayed preceding oral lichenoid areas in early stages. Further studies are needed to understand the impact of these lichenoid areas in proliferative verrucous leukoplakia progression |
Versión do editor: | https://doi.org/10.1111/jop.13317 |
URI: | http://hdl.handle.net/10347/29278 |
DOI: | 10.1111/jop.13317 |
E-ISSN: | 1600-0714 |
Dereitos: | © 2022 The Authors. Journal of Oral Pathology & Medicine published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited Atribución 4.0 Internacional |
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© 2022 The Authors. Journal of Oral Pathology & Medicine published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited
© 2022 The Authors. Journal of Oral Pathology & Medicine published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited