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http://hdl.handle.net/10362/148881
Título: | Longitudinal IgG antibody responses to Plasmodium vivax blood-stage antigens during and after acute vivax malaria in individuals living in the Brazilian Amazon |
Autor: | Tashi, Tenzin Upadhye, Aditi Kundu, Prasun Wu, Chunxiang Menant, Sébastien Soares, Roberta Reis Ferreira, Marcelo U. Longley, Rhea J. Mueller, Ivo Hoang, Quyen Q. Tham, Wai Hong Rayner, Julian C. Scopel, Kézia K.G. Lima-Junior, Josué C. Tran, Tuan M. |
Palavras-chave: | malaria vaccines Plasmodium falciparum Plasmodium vivax natural antibody responses RZ Other systems of medicine QR180 Immunology Public Health, Environmental and Occupational Health Infectious Diseases SDG 3 - Good Health and Well-being |
Data: | Nov-2022 |
Resumo: | Background To make progress towards malaria elimination, a highly effective vaccine targeting Plasmo-dium vivax is urgently needed. Evaluating the kinetics of natural antibody responses to vaccine candidate antigens after acute vivax malaria can inform the design of serological markers of exposure and vaccines. Methodology/Principal findings The responses of IgG antibodies to 9 P. vivax vaccine candidate antigens were evaluated in longitudinal serum samples from Brazilian individuals collected at the time of acute vivax malaria and 30, 60, and 180 days afterwards. Antigen-specific IgG correlations, seropreva-lence, and half-lives were determined for each antigen using the longitudinal data. Antibody reactivities against Pv41 and PVX_081550 strongly correlated with each other at each of the four time points. The analysis identified robust responses in terms of magnitude and seroprevalence against Pv41 and PvGAMA at 30 and 60 days. Among the 8 P. vivax antigens demonstrating >50% seropositivity across all individuals, antibodies specific to PVX_081550 had the longest half-life (100 days; 95% CI, 83–130 days), followed by PvRBP2b (91 days; 95% CI, 76–110 days) and Pv12 (82 days; 95% CI, 64–110 days). Conclusion/Significance This study provides an in-depth assessment of the kinetics of antibody responses to key vaccine candidate antigens in Brazilians with acute vivax malaria. Follow-up studies are needed to determine whether the longer-lived antibody responses induced by natural infection are effective in controlling blood-stage infection and mediating clinical protection. |
Descrição: | Funding Information: This project was funded with support from the Indiana Clinical and Translational Sciences Institute funded, in part by Grant Number UL1TR002529 from the National Institutes of Health (NIH), National Center for Advancing Translational Sciences, Clinical and Translational Sciences Award. T.M.T was supported by NIH K08AI125682. Additional support was provided by NIH R01 AI137154 (J.C.R). The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH. W.H.T. is a Howard Hughes Medical Institute-Wellcome Trust International Research Scholar (208693/Z/17/Z) and supported by National Health and Medical Research Council of Australia (NHMRC) (GNT1160042, GNT1154937). R.J.L. and I.M. are also supported by the NHMRC (GNT1173210 to R.J.L., GNT1092789, GNT1134989, GNT1132975 and GNT1043345 to I. M.). The original field study was supported by Fundação de Amparo à Pesquisa de Minas Gerais (FAPEMIG, APQ-00769-12) and Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq: 470315/2012-1). R.N.R.S. and M.U.F. were recipients of CAPES doctoral and CNPq senior research fellowships, respectively. Q.Q.H. acknowledges funding from the NIH (R01GM111639, R01GM115844) and the Michael J. Fox Foundation. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Publisher Copyright: © 2022, Public Library of Science. All rights reserved. |
Peer review: | yes |
URI: | http://hdl.handle.net/10362/148881 |
DOI: | https://doi.org/10.1371/journal.pntd.0010773 |
ISSN: | 1935-2727 |
Aparece nas colecções: | Home collection (IHMT) |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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Longitudinal_IgG_antibody_responses_to.pdf | 2,48 MB | Adobe PDF | Ver/Abrir |
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