Utilize este identificador para referenciar este registo:
http://hdl.handle.net/10400.14/19931
Título: | Hydroxyapatite-based materials of marine origin: a bioactivity and sintering study |
Autor: | Piccirillo, C. Pullar, R. C. Costa, E. Santos-Silva, A. Pintado, Manuela Castro, Paula M. L. |
Palavras-chave: | Hydroxyapatite Bioactivity Haemolysis Sintering |
Data: | 2015 |
Editora: | Elsevier |
Resumo: | Single phase hydroxyapatite (HAp) and biphasic material hydroxyapatite/beta-tricalcium phosphate (HAp/beta-TCP) were obtained from a marine source (Atlantic cod fish bones). Here we report a study on the biological properties of these materials, including cytotoxicity, bioactivity and haemocompatibility. Results showed that the materials are not cytotoxic, neither in their powder nor in pellet form; indeed growth of Saos-2 cells was comparable to that of commercial. The haemolysis rate was lower than 2%; hence the materials can be classified as non-haemolytic. Moreover, when immersed in Simulated Body Fluid (SBF), crystal formation was observed on the surface of both materials. The sintering behaviour of the samples was also studied; both powders showed very high sinterability (density higher than 95% of the theoretical value). Overall, these results confirm the suitability of these materials for biomedical applications. |
Peer review: | yes |
URI: | http://hdl.handle.net/10400.14/19931 |
DOI: | 10.1016/j.msec.2015.03.020 |
ISSN: | 0928-4931 |
Aparece nas colecções: | CBQF - Artigos / Articles |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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19741706.pdf | 1,15 MB | Adobe PDF | Ver/Abrir Acesso Restrito. Solicitar cópia ao autor! |
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