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http://hdl.handle.net/10400.16/2390
Título: | Gastroenteropancreatic Neuroendocrine Neoplasia Characterization in Portugal: Results from the NETs Study Group of the Portuguese Society of Endocrinology, Diabetes and Metabolism |
Autor: | Santos, A. Vinagre, J. Soares, P. Claro, I. Sanches, A. Gomes, L. Fernandes, I. Catarino, A. Preto, J. Pereira, B. Marques, A. Rodrigues, F. Amaral, C. Rocha, G. Mellidez, J. Simões, H. Lopes, J. Bugalho, M. |
Data: | 2019 |
Editora: | Hindawi |
Citação: | Santos AP, Vinagre J, Soares P, et al. Gastroenteropancreatic Neuroendocrine Neoplasia Characterization in Portugal: Results from the NETs Study Group of the Portuguese Society of Endocrinology, Diabetes and Metabolism. Int J Endocrinol. 2019;2019:4518742. Published 2019 Aug 1. doi:10.1155/2019/4518742 |
Resumo: | Background: The incidence of gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) has been increasing in the last five decades, but there is no large-scale data regarding these tumours in Portugal. We conducted a cross-sectional, multicentric study in main Portuguese centers to evaluate the clinical, pathological, and therapeutic profile of GEP-NENs. Methods: From November, 2012, to July, 2014, data from 293 patients diagnosed with GEP-NENs from 15 centers in Portugal was collected and registered in an online electronic platform. Results: Median age at diagnosis was 56.5 (range: 15-87) years with a preponderance of females (54.6%). The most frequent primary sites were the pancreas (31.1%), jejunum-ileum (24.2%), stomach (13.7%), and rectum (8.5%). Data regarding hormonal status was not available in most patients (82.3%). Stratified by the tumour grade (WHO 2010 classification), we observed 64.0% of NET G1, 24.7% of NET G2, and 11.3% of NEC. Poorly differentiated tumours occurred mainly in older patients (p = 0.017), were larger (p < 0.001), and presented more vascular (p = 0.004) and lymphatic (p = 0.001) invasion. At the time of diagnosis, 44.4% of GEP-NENs presented metastatic disease. Surgery (79.6%) and somatostatin analogues (30.7%) were the most frequently used therapies of GEP-NENs with reported grading. Conclusion: In general, Portuguese patients with GEP-NENs presented similar characteristics to other populations described in the literature. This cross-sectional study represents the first step to establish a national database of GEP-NENs that may aid in understanding the clinical and epidemiological features of these tumours in Portugal. Methods: From November, 2012, to July, 2014, data from 293 patients diagnosed with GEP-NENs from 15 centers in Portugal was collected and registered in an online electronic platform. Results: Median age at diagnosis was 56.5 (range: 15-87) years with a preponderance of females (54.6%). The most frequent primary sites were the pancreas (31.1%), jejunum-ileum (24.2%), stomach (13.7%), and rectum (8.5%). Data regarding hormonal status was not available in most patients (82.3%). Stratified by the tumour grade (WHO 2010 classification), we observed 64.0% of NET G1, 24.7% of NET G2, and 11.3% of NEC. Poorly differentiated tumours occurred mainly in older patients (p = 0.017), were larger (p < 0.001), and presented more vascular (p = 0.004) and lymphatic (p = 0.001) invasion. At the time of diagnosis, 44.4% of GEP-NENs presented metastatic disease. Surgery (79.6%) and somatostatin analogues (30.7%) were the most frequently used therapies of GEP-NENs with reported grading. Conclusion: In general, Portuguese patients with GEP-NENs presented similar characteristics to other populations described in the literature. This cross-sectional study represents the first step to establish a national database of GEP-NENs that may aid in understanding the clinical and epidemiological features of these tumours in Portugal. |
Peer review: | yes |
URI: | http://hdl.handle.net/10400.16/2390 |
DOI: | 10.1155/2019/4518742 |
ISSN: | 1687-8337 1687-8345 |
Versão do Editor: | https://www.hindawi.com/journals/ije/2019/4518742/ |
Aparece nas colecções: | SE - Artigos publicados em revistas indexadas na Pubmed/Medline |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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Gastroenteropancreatic Neuroendocrine Neoplasia.pdf | 1,83 MB | Adobe PDF | Ver/Abrir | |
Santos-2020-Erratum-to-gastroenteropancreatic-n.pdf | 1,17 MB | Adobe PDF | Ver/Abrir |
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