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http://hdl.handle.net/10400.17/3485
Título: | Timing of Disease Occurrence and Hepatic Resection on Long-Term Outcome of Patients with Neuroendocrine Liver Metastasis |
Autor: | Zhang, XF Beal, EW Weiss, M Aldrighetti, L Poultsides, GA Bauer, TW Fields, RC Maithel, SK Pinto Marques, H Pawlik, TM |
Palavras-chave: | Aged Databases, Factual Female Follow-Up Studies Hepatectomy Humans Incidence Liver Neoplasms Male Middle Aged Neoplasm Recurrence, Local Neuroendocrine Tumors Prognosis Propensity Score Time-to-Treatment HCC CIR |
Data: | Fev-2018 |
Editora: | Wiley |
Citação: | J Surg Oncol. 2018 Feb;117(2):171-181. |
Resumo: | Background and objectives: The objective of the study was to evaluate the impact of timing of disease occurrence and hepatic resection on long-term outcome of neuroendocrine liver metastasis (NELM). Methods: A total of 420 patients undergoing curative-intent resection for NELM were identified from a multi-institutional database. Date of primary resection, NELM detection and resection, intraoperative details, disease-specific (DSS), and recurrence-free survival (RFS) were obtained. Results: A total of 243 (57.9%) patients had synchronous NELM, while 177 (42.1%) developed metachronous NELM. On propensity score matching (PSM), patients with synchronous versus metachronous NELM had comparable DSS (10-year DSS, 76.2% vs 85.9%, P = 0.105), yet a worse RFS (10-year RFS, 34.1% vs 59.8%, P = 0.008). DSS and RFS were comparable regardless of operative approach (simultaneous vs staged, both P > 0.1). Among patients who developed metachronous NELM, no difference in long-term outcomes were identified between early (≤2 years, n = 102, 57.6%) and late (>2 years, n = 68, 42.4%) disease on PSM (both P > 0.1). Conclusions: Patients with synchronous NELM had a higher risk of tumor recurrence after hepatic resection versus patients with metachronous disease. The time to development of metachronous NELM did not affect long-term outcome. Curative-intent hepatic resection should be considered for patients who develop NELM regardless of the timing of disease presentation. |
Peer review: | yes |
URI: | http://hdl.handle.net/10400.17/3485 |
DOI: | 10.1002/jso.24832 |
Aparece nas colecções: | CIR - Artigos |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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J Surg Oncol 2018.pdf | 1,27 MB | Adobe PDF | Ver/Abrir |
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