Utilize este identificador para referenciar este registo:
http://hdl.handle.net/10400.17/3729
Título: | Early Versus Late Recurrence of Hepatocellular Carcinoma After Surgical Resection Based on Post-Recurrence Survival: an International Multi-Institutional Analysis |
Autor: | Wei, T Zhang, XF Bagante, F Ratti, F Pinto Marques, H Silva, S Soubrane, O Lam, V Poultsides, G Popescu, I Grigorie, R Alexandrescu, S Martel, G Workneh, A Guglielmi, A Hugh, T Lv, Y Aldrighetti, L Pawlik, T |
Palavras-chave: | Hepatectomy Humans Neoplasm Recurrence, Local Prognosis Retrospective Studies Risk Factors Carcinoma, Hepatocellular Liver Neoplasms HCC CIR |
Data: | 2021 |
Editora: | Springer |
Citação: | J Gastrointest Surg. 2021 Jan;25(1):125-133. |
Resumo: | Background: To define early versus late recurrence based on post-recurrence survival (PRS) among patients undergoing curative resection for hepatocellular carcinoma (HCC). Methods: Patients who underwent curative-intent resection for HCC between 2000 and 2017 were identified from an international multi-institutional database. The optimal cut-off time point to discriminate early versus late recurrence was determined relative to PRS. Results: Among 1004 patients, 443 (44.1%) patients experienced recurrence with a median recurrence-free survival time of 12 months. A cut-off time point of 8 months was defined as the optimal threshold based on sensitivity analyses relative to PRS for early (n = 165, 37.2%) versus late relapse (n = 278, 62.8%) (p = 0.008). Early recurrence was associated with worse PRS (median PRS, 27.0 vs. 43.0 months, p = 0.019), as well as overall survival (OS) (median OS, 32.0 versus 74.0 months, p < 0.001) versus late recurrence. In addition, patients who recurred early were more likely to recur at extra- ± intrahepatic (35.5% vs. 19.8%, p = 0.003) sites and were less likely to have the recurrence treated with curative intent (33.8% vs. 45.7%, p = 0.08). Patients undergoing curative re-treatment of late recurrence had a comparable OS with patients who had no recurrence (median OS, 139.0 vs. 140.0 months); patients with early recurrence had inferior OS after curative re-treatment versus patients with no recurrence (median OS, 69.0 vs. 140.0 months, p = 0.036), yet still better than patients who received palliative treatment for early recurrence (median OS, 69.0 vs. 21.0 months, p < 0.001). Conclusions: Eight months was identified as the cut-off value to differentiate early versus late recurrence. Curative-intent treatment for recurrent intrahepatic tumors was associated with reasonable long-term outcomes. |
Peer review: | yes |
URI: | http://hdl.handle.net/10400.17/3729 |
DOI: | 10.1007/s11605-020-04553-2 |
Aparece nas colecções: | CIR - Artigos |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
---|---|---|---|---|
J Gastrointest Surg 2021 125.pdf | 555,21 kB | Adobe PDF | Ver/Abrir |
Todos os registos no repositório estão protegidos por leis de copyright, com todos os direitos reservados.