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http://hdl.handle.net/10400.17/4221
Título: | Practical Guide for the Use of PCSK9 Inhibitors in Portugal |
Outros títulos: | Guia Prático para a Utilização dos Inibidores da PCSK9 em Portugal |
Autor: | Fontes-Carvalho, R Marques da Silva, P Rodrigues, E Araújo, F Gavina, C Ferreira, J Morais, J |
Palavras-chave: | HSM MED Anticholesteremic Agents / therapeutic use Cholesterol, LDL / blood* Cholesterol, LDL / drug effects Dyslipidemias / blood Dyslipidemias / drug therapy* Dyslipidemias / epidemiology Ezetimibe / therapeutic use* Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use* PCSK9 Inhibitors* Incidence Portugal / epidemiology |
Data: | Jun-2019 |
Editora: | Elsevier España |
Citação: | Rev Port Cardiol (Engl Ed) . 2019 Jun;38(6):391-405. |
Resumo: | Reducing low-density lipoprotein cholesterol (LDL-C) levels is one of the most important strategies for reducing the risk of cardiovascular events. However, in clinical practice, a high proportion of patients do not achieve recommended LDL-C levels through lifestyle and lipid-lowering therapy with statins and ezetimibe. PCSK9 inhibitors (PCSK9i) are a new therapeutic option that significantly (50-60%) reduces LDL-C levels, which in clinical trials translates into an additional reduction in risk for cardiovascular events, and has a good safety profile. However, it is a high-cost therapy, and therefore its use in clinical practice should take its cost-effectiveness into account. Priority should be given to use in patients at higher cardiovascular risk and those in whom high LDL-C levels persist despite optimal lipid-lowering therapy. This consensus document aims to summarize the main data on the clinical use of PCSK9i and to make recommendations for Portugal on the profile of patients who may benefit most from this therapy. |
Peer review: | yes |
URI: | http://hdl.handle.net/10400.17/4221 |
DOI: | 10.1016/j.repc.2019.05.005. |
Aparece nas colecções: | MED - Artigos |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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RPC 2019 391.pdf | 1,49 MB | Adobe PDF | Ver/Abrir |
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