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http://hdl.handle.net/10400.18/6556
Título: | Setting up a collaborative European human biological monitoring study on occupational exposure to hexavalent chromium |
Autor: | Santonen, Tiina Alimonti, Alessandro Bocca, Beatrice Duca, Radu Corneliu Galea, Karen S Godderis, Lode Göen, Thomas Gomes, Bruno Hanser, Ogier Iavicoli, Ivo Janasik, Beata Jones, Kate Kiilunen, Mirja Koch, Holger M Leese, Elizabeth Leso, Veruscka Louro, Henriqueta Ndaw, Sophie Porras, Simo P Robert, Alain Ruggieri, Flavia Scheepers, Paul T J Silva, Maria J Viegas, Susana Wasowicz, Wojciech Castano, Argelia Sepai, Ovnair |
Palavras-chave: | Biomonitoring Human Biomonitoring Hexavalent chromium Occupational Exposure Effect Markers Electroplating Exhaled Breath Condensate Multicenter Study Welding Genotoxicidade Ambiental |
Data: | 10-Jul-2019 |
Editora: | Elsevier/ Academic Press |
Citação: | Environ Res. 2019 Oct;177:108583. doi: 10.1016/j.envres.2019.108583. Epub 2019 Jul 10 |
Resumo: | The EU human biomonitoring initiative, HBM4EU, aims to co-ordinate and advance human biomonitoring (HBM) across Europe. Within its remit, the project is gathering new, policy relevant, EU-wide data on occupational exposure to relevant priority chemicals and developing new approaches for occupational biomonitoring. In this manuscript, the hexavalent chromium [Cr(VI)] study design is presented as the first example of this HBM4EU approach. This study involves eight European countries and plans to recruit 400 workers performing Cr(VI) surface treatment e.g. electroplating or stainless steel welding activities. The aim is to collect new data on current occupational exposure to Cr(VI) in Europe and to test new methods for Cr biomonitoring, specifically the analysis of Cr(VI) in exhaled breath condensate (EBC) and Cr in red blood cells (RBC) in addition to traditional urinary total Cr analyses. Furthermore, exposure data will be complemented with early biological effects data, including genetic and epigenetic effects. Personal air samples and wipe samples are collected in parallel to help informing the biomonitoring results. We present standard operational procedures (SOPs) to support the harmonized methodologies for the collection of occupational hygiene and HBM samples in different countries. Highlights: Pan-European human biomonitoring (HBM) study on occupational exposure to Cr(VI); Harmonized protocols for collecting HBM, occupational hygiene and contextual data; Broad set-up to create meaningful data for EU decision making on Cr(VI) exposure; New biomarkers for exposure to Cr(VI) are piloted; Correlating different exposure parameters to understand the fate of chromium. |
Peer review: | yes |
URI: | http://hdl.handle.net/10400.18/6556 |
DOI: | 10.1016/j.envres.2019.108583 |
ISSN: | 0013-9351 |
Versão do Editor: | https://www.sciencedirect.com/science/article/pii/S0013935119303809?via%3Dihub |
Aparece nas colecções: | DGH - Artigos em revistas internacionais |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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Santonen 2019 Cr study design.pdf | 959,73 kB | Adobe PDF | Ver/Abrir Acesso Restrito. Solicitar cópia ao autor! |
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