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http://hdl.handle.net/10400.18/8526
Título: | Helicobacter pylori infection: from standard to alternative treatment strategies |
Autor: | Sousa, Cláudia Ferreira, Rute Azevedo, Nuno F. Oleastro, Mónica Azeredo, Joana Figueiredo, Ceu Melo, Luís D.R. |
Palavras-chave: | Heliocbacter pylori Alternative Treatments Antibiotic Resistance Infecções Gastrointestinais |
Data: | Mai-2022 |
Editora: | Taylor and Francis |
Citação: | Crit Rev Microbiol. 2022 May;48(3):376-396. doi: 10.1080/1040841X.2021.1975643. Epub 2021 Sep 27 |
Resumo: | Helicobacter pylori is the major component of the gastric microbiome of infected individuals and one of the aetiological factors of chronic gastritis, peptic ulcer disease and gastric cancer. The increasing resistance to antibiotics worldwide has made the treatment of H. pylori infection a challenge. As a way to overhaul the efficacy of currently used H. pylori antibiotic-based eradication therapies, alternative treatment strategies are being devised. These include probiotics and prebiotics as adjuvants in H. pylori treatment, antimicrobial peptides as alternatives to antibiotics, photodynamic therapy ingestible devices, microparticles and nanoparticles applied as drug delivery systems, vaccines, natural products, and phage therapy. This review provides an updated synopsis of these emerging H. pylori control strategies and discusses the advantages, hurdles, and challenges associated with their development and implementation. An effective human vaccine would be a major achievement although, until now, projects regarding vaccine development have failed or were discontinued. Numerous natural products have demonstrated anti-H. pylori activity, mostly in vitro, but further clinical studies are needed to fully disclose their role in H. pylori eradication. Finally, phage therapy has the potential to emerge as a valid alternative, but major challenges remain, namely the isolation of more H. pylori strictly virulent bacterio(phages). |
Peer review: | yes |
URI: | http://hdl.handle.net/10400.18/8526 |
DOI: | 10.1080/1040841X.2021.1975643 |
ISSN: | 1040-841X |
Versão do Editor: | https://www.tandfonline.com/doi/full/10.1080/1040841X.2021.1975643 |
Aparece nas colecções: | DDI - Artigos em revistas internacionais |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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Helicobacter pylori infection from standard to alternative treatment strategies.pdf | 2,94 MB | Adobe PDF | Ver/Abrir Acesso Restrito. Solicitar cópia ao autor! |
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