Utilize este identificador para referenciar este registo:
http://hdl.handle.net/10400.26/36958
Título: | Profiling Persistent Asthma Phenotypes in Adolescents: A Longitudinal Diagnostic Evaluation from the INSPIRERS Studies |
Autor: | Amaral, Rita Jácome, Cristina Almeida, Rute Pereira, Ana Margarida Alves-Correia, Magna Mendes, Sandra Rodrigues, José Carlos Cidrais Carvalho, Joana Araújo, Luís Costa, Alberto Silva, Armandina Teixeira, Maria Fernanda Ferreira-Magalhães, Manuel Alves, Rodrigo Rodrigues Moreira, Ana Sofia Fernandes, Ricardo M. Ferreira, Rosário Pinto, Paula Leiria Neuparth, Nuno Bordalo, Diana Bom, Ana Todo Cálix, Maria José Ferreira, Tânia Gomes, Joana Vidal, Carmen Mendes, Ana Vasconcelos, Maria João Silva, Pedro Morais Ferraz, José Morête, Ana Pinto, Claúdia Sofia Santos, Natacha Loureiro, Claúdia Chaves Arrobas, Ana Marques, Maria Luís Lozoya, Carlos Lopes, Cristina Cardia, Francisca Loureiro, Carla Chaves Câmara, Raquel Vieira, Inês Silva, Sofia da Silva, Eurico Rodrigues, Natalina Fonseca, João A. |
Palavras-chave: | Adolescent Female Humans Male Phenotype Portugal Prospective Studies Spain Asthma |
Data: | 24-Jan-2021 |
Editora: | MDPI |
Citação: | Amaral, R.; Jácome, C.; Almeida, R.; Pereira, A.M.; Alves-Correia, M.; Mendes, S.; Rodrigues, J.C.C.; Carvalho, J.; Araújo, L.; Costa, A.; et al. Profiling Persistent Asthma Phenotypes in Adolescents: A Longitudinal Diagnostic Evaluation from the INSPIRERS Studies. Int. J. Environ. Res. Public Health 2021, 18, 1015. https://doi.org/10.3390/ijerph 18031015 |
Resumo: | We aimed to identify persistent asthma phenotypes among adolescents and to evaluate longitudinally asthma-related outcomes across phenotypes. Adolescents (13-17 years) from the prospective, observational, and multicenter INSPIRERS studies, conducted in Portugal and Spain, were included (n = 162). Latent class analysis was applied to demographic, environmental, and clinical variables, collected at a baseline medical visit. Longitudinal differences in clinical variables were assessed at a 4-month follow-up telephone contact (n = 128). Three classes/phenotypes of persistent asthma were identified. Adolescents in class 1 (n = 87) were highly symptomatic at baseline and presented the highest number of unscheduled healthcare visits per month and exacerbations per month, both at baseline and follow-up. Class 2 (n = 32) was characterized by female predominance, more frequent obesity, and uncontrolled upper/lower airways symptoms at baseline. At follow-up, there was a significant increase in the proportion of controlled lower airway symptoms (p < 0.001). Class 3 (n = 43) included mostly males with controlled lower airways symptoms; at follow-up, while keeping symptom control, there was a significant increase in exacerbations/month (p = 0.015). We have identified distinct phenotypes of persistent asthma in adolescents with different patterns in longitudinal asthma-related outcomes, supporting the importance of profiling asthma phenotypes in predicting disease outcomes that might inform targeted interventions and reduce future risk. |
Peer review: | yes |
URI: | http://hdl.handle.net/10400.26/36958 |
DOI: | 10.3390/ijerph18031015 |
Versão do Editor: | https://www.mdpi.com/1660-4601/18/3/1015 |
Aparece nas colecções: | ACeS DL - Artigos Científicos publicados |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
---|---|---|---|---|
Amaral 2021.pdf | 871,74 kB | Adobe PDF | Ver/Abrir |
Todos os registos no repositório estão protegidos por leis de copyright, com todos os direitos reservados.