Utilize este identificador para referenciar este registo:
http://hdl.handle.net/10400.6/7651
Título: | Hormonal regulation of c-KIT receptor and its ligand: implications for human infertility? |
Autor: | Figueira, Marília I Cardoso, HJ Correia, Sara Baptista, Cláudio Socorro, Sílvia |
Palavras-chave: | Androgens c-KIT Estrogens Gonadotropins Infertility |
Data: | Set-2014 |
Resumo: | The c-KIT, a tyrosine kinase receptor, and its ligand the stem cell factor (SCF) play an important role in the production of male and female gametes. The interaction of SCF with c-KIT is required for germ cell survival and growth, and abnormalities in the activity of the SCF/c-KIT system have been associated with human infertility. Recently, it was demonstrated that gonadotropic and sex steroid hormones, among others, regulate the expression of SCF and c-KIT in testicular and ovarian cells. Therefore, the hormonal (de)regulation of SCF/c-KIT system in the testis and ovary may be a cause underpinning infertility. In the present review, we will discuss the effects of hormones modulating the expression levels of SCF and c-KIT in the human gonads. In addition, the implications of hormonal regulation of SCF/c-KIT system for germ cell development and fertility will be highlighted. |
Peer review: | yes |
URI: | http://hdl.handle.net/10400.6/7651 |
DOI: | 10.1016/j.proghi.2014.09.001 |
Aparece nas colecções: | FCS - DCM | Documentos por Auto-Depósito ICI - CICS | Documentos por Auto-Depósito |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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Hormonal regulation of c-KIT receptor and its ligand_ implications for human infertility.pdf | 1,8 MB | Adobe PDF | Ver/Abrir Acesso Restrito. Solicitar cópia ao autor! |
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