Utilize este identificador para referenciar este registo:
http://hdl.handle.net/10400.6/9280
Título: | Obesity, energy balance and spermatogenesis |
Autor: | Oliveira, Pedro F. Sousa, Mário Silva, Branca M. Monteiro, Mariana P Alves, Marco G |
Palavras-chave: | Humans Male Obesity Spermatogenesis Energy Metabolism |
Data: | 2017 |
Resumo: | Obesity has grown to pandemic proportions. It affects an increasing number of children, adolescents and young adults exposed to the silent comorbidities of this disorder for a longer period. Infertility has arisen as one important comorbidity associated with the energy dysfunction promoted by obesity. Spermatogenesis is a highly regulated process that is determined by specific energetic requirements. The reproductive potential of males relies on hormonal-dependent and -independent stimuli that control sperm quality. There are conflicting data concerning the impact of male overweight and obesity on sperm quality, as well as on the possible paternal-induced epigenetic trait inheritance of obesity. In addition, it remains a matter of debate whether massive weight loss induced by lifestyle interventions, drugs or bariatric surgery may or may not benefit obese men seeking fatherhood. Herein, we propose to discuss how energy balance may modulate hormonal signalling and sperm quality in overweight and obese men. We also discuss some molecular mechanisms that mediate obesity-related dysfunction in male reproductive system and how paternal obesity may lead to trait inheritance. Finally, we will discuss how lifestyle modifications and sustained weight loss, particularly the loss achieved by bariatric surgery, may revert some of the deleterious effects of obesity in men and their offspring. |
Peer review: | yes |
URI: | http://hdl.handle.net/10400.6/9280 |
DOI: | 10.1530/REP-17-0018 |
Aparece nas colecções: | FCS - DCM | Documentos por Auto-Depósito ICI - CICS | Documentos por Auto-Depósito |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
---|---|---|---|---|
ARTIGO_77.pdf | 1,88 MB | Adobe PDF | Ver/Abrir |
Todos os registos no repositório estão protegidos por leis de copyright, com todos os direitos reservados.