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http://hdl.handle.net/10400.8/8227
Título: | A Biorefinery Approach to the Biomass of the Seaweed Undaria pinnatifida (Harvey Suringar, 1873): Obtaining Phlorotannins-Enriched Extracts for Wound Healing |
Autor: | Ferreira, Carolina A. M. Félix, Rafael Félix, Carina Januário, Adriana P. Alves, Nuno Novais, Sara C. Dias, Juliana R. Lemos, Marco F.L. |
Palavras-chave: | Phlorotannins Circular economy Antioxidant Antimicrobial Anti-inflammatory |
Data: | 19-Mar-2021 |
Editora: | MDPI |
Citação: | Ferreira, C.A.M.; Félix, R.; Félix, C.; Januário, A.P.; Alves, N.; Novais, S.C.; Dias, J.R.; Lemos, M.F.L. A Biorefinery Approach to the Biomass of the Seaweed Undaria pinnatifida (Harvey Suringar, 1873): Obtaining Phlorotannins-Enriched Extracts for Wound Healing. Biomolecules 2021, 11, 461. https:// doi.org/10.3390/biom11030461 |
Resumo: | Brown seaweeds are recognized sources of compounds with a wide range of properties and applications. Within these compounds, phlorotannins are known to possess several bioactivities (e.g., antioxidant, anti-inflammatory, and antimicrobial) with potential to improve wound healing. To obtain phlorotannins enriched extracts from Undaria pinnatifida, a biorefinery was set using low cost industry-friendly methodologies, such as sequential solid–liquid extraction and liquid–liquid extraction. The obtained extracts were screened for their antioxidant and antimicrobial activity against five common wound pathogens and for their anti-inflammatory potential. The ethanolic wash fraction (wE100) had the highest antioxidant activity (114.61 ± 10.04 mmol·mg−1 extract by Diphenyl-1-picrylhydrazyl (DPPH) and 6.56 ± 1.13 mM eq. Fe II·mg−1 extract by and Ferric Reducing Antioxidant Power (FRAP)), acting efficiently against Gram-negative (Pseudomonas aeruginosa) and Gram-positive (Staphylococcus aureus) bacteria, and showing a nitric oxide production inhibition over 47% when used at 0.01 µg·mL−1 . NMR and FTIR chemical characterization suggested that phlorotannins are present. Obtained fraction wE100 proved to be a promising candidate for further inclusion as wound healing agents, while the remaining fractions analyzed are potential sources for other biotechnological applications, giving emphasis to a biorefinery and circular economy framework to add value to this seaweed and the industry. |
URI: | http://hdl.handle.net/10400.8/8227 |
DOI: | 10.3390/biom11030461 |
Aparece nas colecções: | CDRsp - Artigos em revistas internacionais |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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biomolecules-11-00461.pdf | 1,82 MB | Adobe PDF | Ver/Abrir |
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