Efeito analgésico do extrato metanólico obtido das folhas de Schinus terebinthifolius
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2020
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Estudos anteriores do nosso grupo mostraram os efeitos analgésicos do óleo essencial e extratos de Schinusterebinthifolius.
Os objetivos desta pesquisa foram avaliar propriedades anti-nociceptivas e antiartríticas do extrato metanólico obtido
das folhas de S. terebinthifolius (EMST) em modelos animais experimentais de dor e artrite. O EMST (30 e 100 mg/
kg) reduziu comportamento de lamber a pata como reflexo à dor nas fases neurogênica e inflamatória induzidas pela
formalina em camundongos Swiss. O EMST (100 mg/kg) reduziu a hiperalgesia mecânica induzida por carragenina em
camundongos Swiss. A administração oral do EMST (100 mg/kg) reduziu significativamente a hiperalgesia mecânica
(dia 2, 5, 10 e 20), edema do joelho (dia 2), sensibilidade ao frio (dia 15) e sensibilidade ao calor (dia 20), mas não o
comportamento depressivo (Teste de nado forçado), após o adjuvante completo de Freund (CFA) em camundongos
C57Bl6. O EMST previniu efeitos antinociceptivos na nocicepção de formalina e não interferiu na atividade locomotora
de camundongos Swiss (teste de campo aberto). O EMST foi eficaz na inibição da dor e dos parâmetros artríticos, sem
alterar atividade locomotora ou comportamento depressivo. Os presentes resultados podem abrir novas possibilidades
para o desenvolvimento de novos agentes analgésicos a partir de S. terebinthifolius.
Palavras-chave: Schinus terebinthifolius; Anacardiaceae; roedores; nocicepção, artrite.
Previous studies from our group showed the analgesic effects of essential oil and extracts of Schinusterebinthifolius. The aims of this research were to evaluate the anti-nociceptive, anti-arthritic properties of methanolic extract obtained from S. terebinthifolius (MEST) leaves in animal models of experimental pain and arthritis. The MEST (30 and 100 mg/kg) reduced both phases of formalin induced licking behavior in Swiss mice. The MEST (100 mg/kg) reduced mechanical hyperalgesia induced by carrageenan in swiss mice. The MEST (100 mg/kg) oral administration reduced significantly the mechanical hyperalgesia (day 2, 5, 10, and 20), knee oedema (day 2), cold (day 15) and heat sensitivity (day 20), but not depressive-like behavior (Forced Swim Test), after Complete Freund’s Adjuvant (CFA) in C57Bl6 mice. The MEST prevented the anti-nociceptive effects in formalin nociception and did not interfere with locomotor activity in Swiss mice (open field test). The MEST was effective for the inhibition of pain and arthritic parameters without altering locomotor activity or depressive-like behavior. The present results may open new possibilities for the development of new analgesic agents from S. terebinthifolius. Keywords: Schinus terebinthifolius, Anacardiaceae, rodents, nociception, arthritis.
Previous studies from our group showed the analgesic effects of essential oil and extracts of Schinusterebinthifolius. The aims of this research were to evaluate the anti-nociceptive, anti-arthritic properties of methanolic extract obtained from S. terebinthifolius (MEST) leaves in animal models of experimental pain and arthritis. The MEST (30 and 100 mg/kg) reduced both phases of formalin induced licking behavior in Swiss mice. The MEST (100 mg/kg) reduced mechanical hyperalgesia induced by carrageenan in swiss mice. The MEST (100 mg/kg) oral administration reduced significantly the mechanical hyperalgesia (day 2, 5, 10, and 20), knee oedema (day 2), cold (day 15) and heat sensitivity (day 20), but not depressive-like behavior (Forced Swim Test), after Complete Freund’s Adjuvant (CFA) in C57Bl6 mice. The MEST prevented the anti-nociceptive effects in formalin nociception and did not interfere with locomotor activity in Swiss mice (open field test). The MEST was effective for the inhibition of pain and arthritic parameters without altering locomotor activity or depressive-like behavior. The present results may open new possibilities for the development of new analgesic agents from S. terebinthifolius. Keywords: Schinus terebinthifolius, Anacardiaceae, rodents, nociception, arthritis.
Descrição
Biomedical and biopharmaceutical research : jornal de investigação biomédica e biofarmacêutica
Palavras-chave
MEDICINA, BIOMEDICINA, MAMÍFEROS ROEDORES, NOCICEPÇÃO, ARTRITE, MEDICINE, BIOMEDICINE, RODENTS, NOCICEPTION, ARTHRITIS