Modelo tipo de dermatite atópica em rato
Miniatura indisponível
Data
2014
Título da revista
ISSN da revista
Título do Volume
Editora
Resumo
A dermatite atópica (DA) é um tema importante na dermatologia clínica. Na verdade, a patogénese dessa doença inflamatória crónica da pele, caracterizada principalmente por pele seca e prurido, ainda está longe de ser totalmente
compreendida. A fim de saber mais acerca desta complexa doença, ratos Wistar machos e adultos (n = 10) foram
utilizados como modelo animal, nos quais o tratamento com acetona (AA) foi comparado com o tratamento com
água por 3 dias (AW). No dia 3, uma hora após o último tratamento, a AA mostrou maior perda transepidérmica de
água (TEWL), fluxo sanguíneo capilar e reduzida hidratação quando comparada com AW. A análise comportamental
mostrou que a acção de coçar foi marcadamente mais frequente no grupo AA (n = 5) quando comparado ao grupo
AW (n = 5). Estes resultados justificam a implementação deste modelo animal como uma ferramenta experimental
para investigação da AD.
The Atopic dermatitis (AD) is a most important topic in clinical dermatology. In fact, the pathogenesis of this chronic inflammatory skin disease, primarily characterized by pruritus and dry skin, is still far from being fully understood. To look further into this complex disease, male adult Wistar rats (n = 10) were used as a model where acetone (AA) acted as the active challenger in a 3-day treatment setting, and compared with water (AW). On day 3, one hour after the last treatment, the AA area exhibited higher transepidermal water loss (TEWL), capillary blood flow, and reduced hydration when compared to AW. The scratching behavior was markedly higher in the AA treated group (n = 5) than in the AW group (n = 5). These interesting results justify the application of this model as a clinical experimental tool for AD research.
The Atopic dermatitis (AD) is a most important topic in clinical dermatology. In fact, the pathogenesis of this chronic inflammatory skin disease, primarily characterized by pruritus and dry skin, is still far from being fully understood. To look further into this complex disease, male adult Wistar rats (n = 10) were used as a model where acetone (AA) acted as the active challenger in a 3-day treatment setting, and compared with water (AW). On day 3, one hour after the last treatment, the AA area exhibited higher transepidermal water loss (TEWL), capillary blood flow, and reduced hydration when compared to AW. The scratching behavior was markedly higher in the AA treated group (n = 5) than in the AW group (n = 5). These interesting results justify the application of this model as a clinical experimental tool for AD research.
Descrição
Palavras-chave
MEDICINA, MEDICINE, SKIN DISEASES, DOENÇAS DA PELE, DERMATITE, DERMATITIS, ESTUDOS DE CASO, CASE STUDIES