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http://hdl.handle.net/10451/47166
Título: | Extracellular vesicles in CNS developmental disorders |
Autor: | Gomes, Ana Rita Sangani, Nasim Bahram Fernandes, Tiago G. Diogo, Maria Margarida Curfs, Leopold M. G. Reutelingsperger, Chris P. |
Palavras-chave: | CNS Astrocytes Exosomes Extracellular vesicles Glia Microvesicles Neurodevelopmental disorders Neurons |
Data: | 2020 |
Editora: | MDPI |
Citação: | Int J Mol Sci. 2020 Dec 11;21(24):9428 |
Resumo: | The central nervous system (CNS) is the most complex structure in the body, consisting of multiple cell types with distinct morphology and function. Development of the neuronal circuit and its function rely on a continuous crosstalk between neurons and non-neural cells. It has been widely accepted that extracellular vesicles (EVs), mainly exosomes, are effective entities responsible for intercellular CNS communication. They contain membrane and cytoplasmic proteins, lipids, non-coding RNAs, microRNAs and mRNAs. Their cargo modulates gene and protein expression in recipient cells. Several lines of evidence indicate that EVs play a role in modifying signal transduction with subsequent physiological changes in neurogenesis, gliogenesis, synaptogenesis and network circuit formation and activity, as well as synaptic pruning and myelination. Several studies demonstrate that neural and non-neural EVs play an important role in physiological and pathological neurodevelopment. The present review discusses the role of EVs in various neurodevelopmental disorders and the prospects of using EVs as disease biomarkers and therapeutics. |
Descrição: | © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
Peer review: | yes |
URI: | http://hdl.handle.net/10451/47166 |
DOI: | 10.3390/ijms21249428 |
ISSN: | 1661-6596 |
Versão do Editor: | https://www.mdpi.com/journal/ijms |
Aparece nas colecções: | FM - Artigos em Revistas Internacionais IMM - Artigos em Revistas Internacionais |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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Extracellular_vesicles.pdf | 12,56 MB | Adobe PDF | Ver/Abrir |
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