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http://hdl.handle.net/10451/55225
Título: | IL-10 overexpression predisposes to invasive aspergillosis by suppressing antifungal immunity |
Autor: | Cunha, Cristina Gonçalves, Samuel M. Duarte-Oliveira, Cláudio Leite, Luís Lagrou, Katrien Marques, António Lupiañez, Carmen B. Mesquita, Inês Gaifem, Joana Barbosa, Ana Margarida Pinho Vaz, Carlos Branca, Rosa Campilho, Fernando Freitas, Fátima Ligeiro, Dário Lass-Flörl, Cornelia Löffler, Jürgen Jurado, Manuel Saraiva, Margarida Kurzai, Oliver Rodrigues, Fernando Castro, António G. Silvestre, Ricardo Sainz, Juan Maertens, Johan A. Torrado, Egídio Jacobsen, Ilse D. Lacerda, João Campos, Jr, António Carvalho, Agostinho |
Data: | 2017 |
Editora: | Elsevier |
Citação: | J Allergy Clin Immunol. 2017 Sep;140(3):867-870.e9 |
Resumo: | Proinflammatory immune responses are critically required for antimicrobial host defenses; however, excessive inflammation has the potential to damage host tissues thereby paradoxically contributing to the progression of infection. A central negative regulator of inflammatory responses is IL-10, an immunosuppressive cytokine with a wide variety of functions across multiple cell types. Although the role of IL-10 during infection appears to vary for different microorganisms, a largely detrimental role has been attributed to this cytokine during fungal disease. Given the variable risk of infection and its outcome among patients with comparable predisposing factors, susceptibility to invasive aspergillosis (IA) is thought to rely largely on genetic predisposition. The initial investigation of genetic variability at the IL10 locus led to the identification of single nucleotide polymorphisms (SNPs) influencing its transcriptional activity; thus, IL-10 may be a reasonable candidate for the genetic regulation of susceptibility to IA in high-risk patients. |
Descrição: | © 2017 American Academy of Allergy, Asthma & Immunology |
Peer review: | yes |
URI: | http://hdl.handle.net/10451/55225 |
DOI: | 10.1016/j.jaci.2017.02.034 |
ISSN: | 0091-6749 |
Versão do Editor: | https://www.sciencedirect.com/journal/journal-of-allergy-and-clinical-immunology |
Aparece nas colecções: | FM - Artigos em Revistas Internacionais IMM - Artigos em Revistas Internacionais |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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IL10_overexpression.pdf | 1,1 MB | Adobe PDF | Ver/Abrir |
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