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Título: | Predictors of cardiac involvement in idiopathic inflammatory myopathies |
Autor: | Bandeira, Matilde Dourado, Eduardo Melo, Ana Teresa Martins, Patrícia Fraga, Vanessa Ferraro, José Luís Saraiva, André Sousa, Marlene Parente, Hugo Soares, Catarina Correia, Ana Margarida Almeida, Diogo Esperança Dinis, Sara Paiva Pinto, Ana Sofia Oliveira Pinheiro, Filipe Rato, Maria Seabra Beirão, Tiago Samões, Beatriz Santos, Bernardo Mazeda, Carolina Chícharo, Ana Teodósio Faria, Margarida Neto, Agna Lourenço, Maria Helena Brites, Luísa Rodrigues, Marília Silva-Dinis, Joana Dias, João Madruga Araújo, Filipe C. Martins, Nádia Couto, Maura Valido, Ana Santos, Maria Barreira, Sofia Fonseca, João Eurico Campanilho-Marques, Raquel |
Palavras-chave: | Biomarkers Cardiac involvement Idiopathic inflammatory myopathies Myocarditis Predictors Risk factors |
Data: | 2023 |
Editora: | Frontiers |
Citação: | Front Immunol. 2023 Mar 8;14:1146817 |
Resumo: | Objectives: Idiopathic inflammatory myopathies (IIM) are a group of rare disorders that can affect the heart. This work aimed to find predictors of cardiac involvement in IIM. Methods: Multicenter, open cohort study, including patients registered in the IIM module of the Rheumatic Diseases Portuguese Register (Reuma.pt/Myositis) until January 2022. Patients without cardiac involvement information were excluded. Myo(peri)carditis, dilated cardiomyopathy, conduction abnormalities, and/or premature coronary artery disease were considered. Results: 230 patients were included, 163 (70.9%) of whom were females. Thirteen patients (5.7%) had cardiac involvement. Compared with IIM patients without cardiac involvement, these patients had a lower bilateral manual muscle testing score (MMT) at the peak of muscle weakness [108.0 ± 55.0 vs 147.5 ± 22.0, p=0.008] and more frequently had oesophageal [6/12 (50.0%) vs 33/207 (15.9%), p=0.009] and lung [10/13 (76.9%) vs 68/216 (31.5%), p=0.001] involvements. Anti-SRP antibodies were more commonly identified in patients with cardiac involvement [3/11 (27.3%) vs 9/174 (5.2%), p=0.026]. In the multivariate analysis, positivity for anti-SRP antibodies (OR 104.3, 95% CI: 2.5-4277.8, p=0.014) was a predictor of cardiac involvement, regardless of sex, ethnicity, age at diagnosis, and lung involvement. Sensitivity analysis confirmed these results. Conclusion: Anti-SRP antibodies were predictors of cardiac involvement in our cohort of IIM patients, irrespective of demographical characteristics and lung involvement. We suggest considering frequent screening for heart involvement in anti-SRP-positive IIM patients. |
Descrição: | Copyright © 2023 Bandeira, Dourado, Melo, Martins, Fraga, Ferraro, Saraiva, Sousa, Parente, Soares, Correia, Almeida, Dinis, Pinto, Oliveira Pinheiro, Rato, Beirão, Samões, Santos, Mazeda, Chícharo, Faria, Neto, Lourenço, Brites, Rodrigues, Silva-Dinis, Dias, Araújo, Martins, Couto, Valido, Santos, Barreira, Fonseca and Campanilho-Marques. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
Peer review: | yes |
URI: | http://hdl.handle.net/10451/58066 |
DOI: | 10.3389/fimmu.2023.1146817 |
Versão do Editor: | https://www.frontiersin.org/journals/immunology |
Aparece nas colecções: | IMM - Artigos em Revistas Internacionais FM-CUR-Artigos em Revistas Internacionais |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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Predictors_involvement.pdf | 452,63 kB | Adobe PDF | Ver/Abrir |
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