Designing and conducting randomized controlled trials in palliative care: A summary of discussions from the 2010 clinical research forum of the Australian Palliative Care Clinical Studies Collaborative

Shelby-James, TM; Hardy, J; Agar, M; Yates, P; Mitchell, G; Sanderson, C; Luckett, T; Abernethy, AP; Currow, DC

Designing and conducting randomized controlled trials in palliative care: A summary of discussions from the 2010 clinical research forum of the Australian Palliative Care Clinical Studies Collaborative

Shelby-James, TM Hardy, J Agar, M

Yates, P Mitchell, G Sanderson, C

Luckett, T

Abernethy, AP Currow, DC

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Publication Type:: Journal Article
Citation:: Palliative Medicine, 2012, 26 (8), pp. 1042 - 1047
Issue Date:: 2012-12-01

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Field	Value	Language
dc.contributor.author	Shelby-James, TM	en_US
dc.contributor.author	Hardy, J	en_US
dc.contributor.author	Agar, M https://orcid.org/0000-0002-6756-6119	en_US
dc.contributor.author	Yates, P	en_US
dc.contributor.author	Mitchell, G	en_US
dc.contributor.author	Sanderson, C https://orcid.org/0000-0001-5423-5778	en_US
dc.contributor.author	Luckett, T https://orcid.org/0000-0001-6121-5409	en_US
dc.contributor.author	Abernethy, AP	en_US
dc.contributor.author	Currow, DC https://orcid.org/0000-0003-1988-1250	en_US
dc.date.issued	2012-12-01	en_US
dc.identifier.citation	Palliative Medicine, 2012, 26 (8), pp. 1042 - 1047	en_US
dc.identifier.issn	0269-2163	en_US
dc.identifier.uri	http://hdl.handle.net/10453/111323
dc.description.abstract	Rigorous clinical research in palliative care is challenging but achievable. Trial participants are likely to have deteriorating performance status, co-morbidities and progressive disease. It is difficult to recruit patients, and attrition unrelated to the intervention being trialled is high. The aim of this paper is to highlight practical considerations from a forum held to discuss these issues by active palliative care clinical researchers.To date, the Australian Palliative Care Clinical Studies Collaborative (PaCCSC) has randomized more than 500 participants across 12 sites in 8 Phase III studies. Insights from the 2010 clinical research forum of the PaCCSC are reported. All active Australian researchers in palliative care were invited to present their current research and address three specific questions: (1) What has worked well? (2) What didn't work well? and (3) How should the research be done differently next time?Fourteen studies were presented, including six double-blind, randomized, controlled, multi-site trials run by the PaCCSC. Key recommendations are reported, including guidance on design; methodologies; and strategies for maximizing recruitment and retention. These recommendations will help to inform future trial design and conduct in palliative care. © 2012 The Author(s).	en_US
dc.relation.ispartof	Palliative Medicine	en_US
dc.relation.isbasedon	10.1177/0269216311417036	en_US
dc.subject.classification	Gerontology	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Palliative Care	en_US
dc.subject.mesh	Biomedical Research	en_US
dc.subject.mesh	Research Design	en_US
dc.subject.mesh	Patient Selection	en_US
dc.subject.mesh	Physicians	en_US
dc.subject.mesh	Patients	en_US
dc.subject.mesh	Health Services Research	en_US
dc.subject.mesh	Australia	en_US
dc.subject.mesh	Randomized Controlled Trials as Topic	en_US
dc.title	Designing and conducting randomized controlled trials in palliative care: A summary of discussions from the 2010 clinical research forum of the Australian Palliative Care Clinical Studies Collaborative	en_US
dc.type	Journal Article
utslib.citation.volume	8	en_US
utslib.citation.volume	26	en_US
utslib.for	1117 Public Health and Health Services	en_US
utslib.for	1199 Other Medical and Health Sciences	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/IMPACCT
pubs.organisational-group	/University of Technology Sydney/Students
utslib.copyright.status	closed_access
pubs.issue	8	en_US
pubs.publication-status	Published	en_US
pubs.volume	26	en_US

Abstract:

Rigorous clinical research in palliative care is challenging but achievable. Trial participants are likely to have deteriorating performance status, co-morbidities and progressive disease. It is difficult to recruit patients, and attrition unrelated to the intervention being trialled is high. The aim of this paper is to highlight practical considerations from a forum held to discuss these issues by active palliative care clinical researchers.To date, the Australian Palliative Care Clinical Studies Collaborative (PaCCSC) has randomized more than 500 participants across 12 sites in 8 Phase III studies. Insights from the 2010 clinical research forum of the PaCCSC are reported. All active Australian researchers in palliative care were invited to present their current research and address three specific questions: (1) What has worked well? (2) What didn't work well? and (3) How should the research be done differently next time?Fourteen studies were presented, including six double-blind, randomized, controlled, multi-site trials run by the PaCCSC. Key recommendations are reported, including guidance on design; methodologies; and strategies for maximizing recruitment and retention. These recommendations will help to inform future trial design and conduct in palliative care. © 2012 The Author(s).

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/111323