Vertical bone augmentation induced by ultrathin hydroxyapatite sputtered coated mini titanium implants in a rabbit calvaria model

Wang, X; Zakaria, O; Madi, M; Hao, J; Chou, J; Kasugai, S

Vertical bone augmentation induced by ultrathin hydroxyapatite sputtered coated mini titanium implants in a rabbit calvaria model

Wang, X Zakaria, O Madi, M Hao, J Chou, J

Kasugai, S

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Publication Type:: Journal Article
Citation:: Journal of Biomedical Materials Research - Part B Applied Biomaterials, 2015, 103 (8), pp. 1700 - 1708
Issue Date:: 2015-11-01

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Field	Value	Language
dc.contributor.author	Wang, X	en_US
dc.contributor.author	Zakaria, O	en_US
dc.contributor.author	Madi, M	en_US
dc.contributor.author	Hao, J	en_US
dc.contributor.author	Chou, J https://orcid.org/0000-0002-7472-8016	en_US
dc.contributor.author	Kasugai, S	en_US
dc.date.available	2014-12-02	en_US
dc.date.issued	2015-11-01	en_US
dc.identifier.citation	Journal of Biomedical Materials Research - Part B Applied Biomaterials, 2015, 103 (8), pp. 1700 - 1708	en_US
dc.identifier.issn	1552-4973	en_US
dc.identifier.uri	http://hdl.handle.net/10453/120307
dc.description.abstract	© 2014 Wiley Periodicals, Inc. Background The purpose of this study was to evaluate the vertical new bone formation induced by sputtered HA-coated titanium implants (HA-coated) compared with sandblasted acid-etched titanium implants (noncoated) in a rabbit calvarial model. Materials and method Twenty HA-coated and 20 noncoated titanium implants were divided equally into four groups as HA-coated implant (HA); noncoated implant (NC); HA-coated implant with membrane (HA/M); noncoated implant with membrane (NC/M). All implants were placed 5 mm above the original bone (OB). Collagen membranes were placed over the implants in HA/M and NC/M groups. The animals were sacrificed at 4 weeks (n = 5) and 8 weeks (n = 5). Vertical bone height above OB (VBH, mm) and augmented bone area (ABA, mm2) were analyzed histologically and radiographically. Results At 4 weeks, VBH reached significantly higher level in HA/M group compared with other three groups (p < 0.05). At 8 weeks, significant difference was detected between HA/M and NC groups (p < 0.05). At 4 and 8 weeks, ABA in HA/M group was significantly larger compared with other three groups (p < 0.05). Conclusion The present results indicated that sputtered HA-coated titanium implant together with collagen membrane could be a novel and effective approach for vertical bone augmentation.	en_US
dc.relation.ispartof	Journal of Biomedical Materials Research - Part B Applied Biomaterials	en_US
dc.relation.isbasedon	10.1002/jbm.b.33347	en_US
dc.subject.classification	Biomedical Engineering	en_US
dc.subject.mesh	Skull	en_US
dc.subject.mesh	Animals	en_US
dc.subject.mesh	Rabbits	en_US
dc.subject.mesh	Durapatite	en_US
dc.subject.mesh	Titanium	en_US
dc.subject.mesh	Bone Substitutes	en_US
dc.subject.mesh	Coated Materials, Biocompatible	en_US
dc.subject.mesh	Prostheses and Implants	en_US
dc.title	Vertical bone augmentation induced by ultrathin hydroxyapatite sputtered coated mini titanium implants in a rabbit calvaria model	en_US
dc.type	Journal Article
utslib.citation.volume	8	en_US
utslib.citation.volume	103	en_US
utslib.for	0903 Biomedical Engineering	en_US
utslib.for	0912 Materials Engineering	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology/School of Biomedical Engineering
pubs.organisational-group	/University of Technology Sydney/Strength - CHT - Health Technologies
utslib.copyright.status	closed_access
pubs.issue	8	en_US
pubs.publication-status	Published	en_US
pubs.volume	103	en_US

Abstract:

© 2014 Wiley Periodicals, Inc. Background The purpose of this study was to evaluate the vertical new bone formation induced by sputtered HA-coated titanium implants (HA-coated) compared with sandblasted acid-etched titanium implants (noncoated) in a rabbit calvarial model. Materials and method Twenty HA-coated and 20 noncoated titanium implants were divided equally into four groups as HA-coated implant (HA); noncoated implant (NC); HA-coated implant with membrane (HA/M); noncoated implant with membrane (NC/M). All implants were placed 5 mm above the original bone (OB). Collagen membranes were placed over the implants in HA/M and NC/M groups. The animals were sacrificed at 4 weeks (n = 5) and 8 weeks (n = 5). Vertical bone height above OB (VBH, mm) and augmented bone area (ABA, mm2) were analyzed histologically and radiographically. Results At 4 weeks, VBH reached significantly higher level in HA/M group compared with other three groups (p < 0.05). At 8 weeks, significant difference was detected between HA/M and NC groups (p < 0.05). At 4 and 8 weeks, ABA in HA/M group was significantly larger compared with other three groups (p < 0.05). Conclusion The present results indicated that sputtered HA-coated titanium implant together with collagen membrane could be a novel and effective approach for vertical bone augmentation.

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http://hdl.handle.net/10453/120307