Field |
Value |
Language |
dc.contributor.author |
Pham, NHT |
|
dc.contributor.author |
Joglekar, MV |
|
dc.contributor.author |
Wong, WKM |
|
dc.contributor.author |
Nassif, NT |
|
dc.contributor.author |
Simpson, AM |
|
dc.contributor.author |
Hardikar, AA |
|
dc.date.accessioned |
2023-06-09T11:15:37Z |
|
dc.date.available |
2023-06-09T11:15:37Z |
|
dc.identifier.citation |
Nutrition Reviews |
|
dc.identifier.issn |
0029-6643 |
|
dc.identifier.issn |
1753-4887 |
|
dc.identifier.uri |
http://hdl.handle.net/10453/170685
|
|
dc.description.abstract |
<jats:title>Abstract</jats:title>
<jats:sec>
<jats:title>Context</jats:title>
<jats:p>There is substantial evidence that reduced short-chain fatty acids (SCFAs) in the gut are associated with obesity and type 2 diabetes, although findings from clinical interventions that can increase SCFAs are inconsistent.</jats:p>
</jats:sec>
<jats:sec>
<jats:title>Objective</jats:title>
<jats:p>This systematic review and meta-analysis aimed to assess the effect of SCFA interventions on fasting glucose, fasting insulin, and homeostatic model assessment of insulin resistance (HOMA-IR).</jats:p>
</jats:sec>
<jats:sec>
<jats:title>Data Sources</jats:title>
<jats:p>Relevant articles published up to July 28, 2022, were extracted from PubMed and Embase using the MeSH (Medical Subject Headings) terms of the defined keywords [(short-chain fatty acids) AND (obesity OR diabetes OR insulin sensitivity)] and their synonyms. Data analyses were performed independently by two researchers who used the Cochrane meta-analysis checklist and the PRISMA guidelines.</jats:p>
</jats:sec>
<jats:sec>
<jats:title>Data Extraction</jats:title>
<jats:p>Clinical studies and trials that measured SCFAs and reported glucose homeostasis parameters were included in the analysis. Standardized mean differences (SMDs) with 95%CIs were calculated using a random-effects model in the data extraction tool Review Manager version 5.4 (RevMan 5.4). The risk-of-bias assessment was performed following the Cochrane checklist for randomized and crossover studies.</jats:p>
</jats:sec>
<jats:sec>
<jats:title>Data Analysis</jats:title>
<jats:p>In total, 6040 nonduplicate studies were identified, 23 of which met the defined criteria, reported fasting insulin, fasting glucose, or HOMA-IR values, and reported change in SCFA concentrations post intervention. Meta-analyses of these studies indicated that fasting insulin concentrations were significantly reduced (overall effect: SMD = −0.15; 95%CI = −0.29 to −0.01, P = 0.04) in treatment groups, relative to placebo groups, at the end of the intervention. Studies with a confirmed increase in SCFAs at the end of intervention also had a significant effect on lowering fasting insulin (P = 0.008). Elevated levels of SCFAs, compared with baseline levels, were associated with beneficial effects on HOMA-IR (P &lt; 0.00001). There was no significant change in fasting glucose concentrations.</jats:p>
</jats:sec>
<jats:sec>
<jats:title>Conclusion</jats:title>
<jats:p>Increased postintervention levels of SCFAs are associated with lower fasting insulin concentrations, offering a beneficial effect on insulin sensitivity.</jats:p>
</jats:sec>
<jats:sec>
<jats:title>Systematic Review Registration</jats:title>
<jats:p>PROSPERO registration number CRD42021257248.</jats:p>
</jats:sec> |
|
dc.language |
en |
|
dc.publisher |
Oxford University Press (OUP) |
|
dc.relation.ispartof |
Nutrition Reviews |
|
dc.relation.isbasedon |
10.1093/nutrit/nuad042 |
|
dc.rights |
info:eu-repo/semantics/closedAccess |
|
dc.subject |
11 Medical and Health Sciences, 17 Psychology and Cognitive Sciences |
|
dc.subject.classification |
Nutrition & Dietetics |
|
dc.title |
Short-chain fatty acids and insulin sensitivity: a systematic review and meta-analysis |
|
dc.type |
Journal Article |
|
utslib.for |
11 Medical and Health Sciences |
|
utslib.for |
17 Psychology and Cognitive Sciences |
|
pubs.organisational-group |
/University of Technology Sydney |
|
pubs.organisational-group |
/University of Technology Sydney/Faculty of Science |
|
pubs.organisational-group |
/University of Technology Sydney/Strength - CHT - Health Technologies |
|
pubs.organisational-group |
/University of Technology Sydney/Faculty of Science/School of Life Sciences |
|
pubs.organisational-group |
/University of Technology Sydney/Centre for Health Technologies (CHT) |
|
utslib.copyright.status |
closed_access |
* |
dc.date.updated |
2023-06-09T11:15:35Z |
|
pubs.publication-status |
Published online |
|