Statistical properties of the NOAEL

Leisenring, W; Ryan, L

Statistical properties of the NOAEL

Leisenring, W Ryan, L

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Publication Type:: Journal Article
Citation:: Regulatory Toxicology and Pharmacology, 1992, 15 (PART 2), pp. 161 - 171
Issue Date:: 1992-01-01

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Field	Value	Language
dc.contributor.author	Leisenring, W	en_US
dc.contributor.author	Ryan, L https://orcid.org/0000-0001-5957-2490	en_US
dc.date.issued	1992-01-01	en_US
dc.identifier.citation	Regulatory Toxicology and Pharmacology, 1992, 15 (PART 2), pp. 161 - 171	en_US
dc.identifier.issn	0273-2300	en_US
dc.identifier.uri	http://hdl.handle.net/10453/26214
dc.description.abstract	The use of the no observed adverse effect level (NOAEL) in setting allowable exposure levels for noncancer endpoints is a source of controversy. Based on computer simulations and empirical studies, several authors have criticized the use of the NOAEL in terms of its sensitivity to sample size and its high sampling variability from experiment to experiment. The purpose of this paper is to derive the statistical distribution of the NOAEL. Using Weibull models, we investigate the impact of the shape of the underlying dose-response curve on the distribution of the NOAEL. The results confirm previous criticisms of the NOAEL and show that average risk levels associated with the NOAEL may be substantial. These results provide additional motivation for developing alternative approaches to risk assessment. © 1992.	en_US
dc.relation.ispartof	Regulatory Toxicology and Pharmacology	en_US
dc.relation.isbasedon	10.1016/0273-2300(92)90047-D	en_US
dc.subject.classification	Toxicology	en_US
dc.subject.mesh	Animals	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Risk	en_US
dc.subject.mesh	Toxicology	en_US
dc.subject.mesh	Dose-Response Relationship, Drug	en_US
dc.subject.mesh	Models, Biological	en_US
dc.title	Statistical properties of the NOAEL	en_US
dc.type	Journal Article
utslib.citation.volume	PART 2	en_US
utslib.citation.volume	15	en_US
utslib.for	010402 Biostatistics	en_US
utslib.for	1115 Pharmacology and Pharmaceutical Sciences	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Mathematical and Physical Sciences
utslib.copyright.status	closed_access
pubs.issue	PART 2	en_US
pubs.publication-status	Published	en_US
pubs.volume	15	en_US

Abstract:

The use of the no observed adverse effect level (NOAEL) in setting allowable exposure levels for noncancer endpoints is a source of controversy. Based on computer simulations and empirical studies, several authors have criticized the use of the NOAEL in terms of its sensitivity to sample size and its high sampling variability from experiment to experiment. The purpose of this paper is to derive the statistical distribution of the NOAEL. Using Weibull models, we investigate the impact of the shape of the underlying dose-response curve on the distribution of the NOAEL. The results confirm previous criticisms of the NOAEL and show that average risk levels associated with the NOAEL may be substantial. These results provide additional motivation for developing alternative approaches to risk assessment. © 1992.

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http://hdl.handle.net/10453/26214