Biological versus chronological aging: JACC focus seminar
Entity
UAM. Departamento de MedicinaPublisher
ElsevierDate
2020-03-03Citation
10.1016/j.jacc.2019.11.062
Journal of the American College of Cardiology 75.8 (2020): 919 - 930
ISSN
0735-1097DOI
10.1016/j.jacc.2019.11.062Funded by
The CNIC is supported by the MCNU, the ISCIII, and the Pro CNIC Foundation and is a Severo Ochoa Center of Excellence (SEV-2015-0505). Work in Dr. Andrés’ laboratory is supported by the Spanish Ministerio de Ciencia, Innovación y Universidades (MCNU) (SAF2016- 79490-R) and the Instituto de Salud Carlos III (ISCIII) (AC16/00091, AC17/00067, and CB16/11/00405) with cofunding from the European Regional Development Fund (ERDF/FEDER, “Una manera de hacer Europa”) and the Fundació Marató TV3 (122/C/2015)Project
Gobierno de España. SAF2016-79490-R; Gobierno de España. AC16/00091; Gobierno de España. AC17/00067; Gobierno de España. CB16/11/00405Editor's Version
https://doi.org/10.1016/j.jacc.2019.11.062Subjects
antiaging therapy; biological age; biological age biomarkers; chronological age; vascular disease; MedicinaRights
© 2020 The AuthorsEsta obra está bajo una licencia de Creative Commons Reconocimiento-NoComercial-SinObraDerivada 4.0 Internacional.
Abstract
Aging is the main risk factor for vascular disease and ensuing cardiovascular and cerebrovascular events, the leading causes of death worldwide. In a progressively aging population, it is essential to develop early-life biomarkers that efficiently identify individuals who are at high risk of developing accelerated vascular damage, with the ultimate goal of improving primary prevention and reducing the health care and socioeconomic impact of age-related cardiovascular disease. Studies in experimental models and humans have identified 9 highly interconnected hallmark processes driving mammalian aging. However, strategies to extend health span and life span require understanding of interindividual differences in age-dependent functional decline, known as biological aging. This review summarizes the current knowledge on biological age biomarkers, factors influencing biological aging, and antiaging interventions, with a focus on vascular aspects of the aging process and its cardiovascular disease related manifestations
Files in this item
Google Scholar:Hamczyk, Magda R.
-
Nevado, Rosa M.
-
Barettino, Ana
-
Fuster, Valentín
-
Andrés, Vicente
This item appears in the following Collection(s)
- Producción científica de la UAM [20729]
Related items
Showing items related by title, author, creator and subject.
-
Low-dose aspirin for primary revention of cardiovascular disease: Use patterns and impact across race and ethnicity in the southern community cohort study
Fernández-Jiménez, Rodrigo; Wang, Thomas J.; Fuster, Valentín; Blot, William J.
2019 -
Dietary patterns and cardiovascular risk factors in Spanish adolescents: A cross-sectional analysis of the SI! Program for Health Promotion in secondary schools
Bodega, Patricia; Fenández Alvira, Juan Miguel; Santos Beneit, Gloria; Cos Gandoy, Amaya de; Fernández Jiménez, Rodrigo; Moreno, Luis Alberto; Miguel, Mercedes de; Carral, Vanesa; Orrit, Xavier; Carvajal, Isabel; Storniolo, Carolina E.; Tresserra-Rimbau, Anna; Doménech, Mónica; Estruch, Ramón; Lamuela Raventós, Rosa María; Fuster, Valentín
2019-09-26