Hypothyroidism confers tolerance to cerebral malaria
Author
Rodriguez-Muñoz, Diego; Sánchez, Ángela; Pérez-Benavente, Susana; Contreras-Jurado, Constanza; Montero-Pedrazuela, Ana; Toledo-Castillo, Marta; Gutiérrez-Hernández, María; Rodrigues Díez, Raquel; Folgueira, Cintia; Briones, Ana M.; Sabio, Guadalupe; Monedero-Cobeta, Ignacio; Chávez-Coira, Irene; Castejón, David; Fernández-Valle, Encarnación; Regadera González, Javier Fco.; Bautista, José M.; Aranda, Ana; Alemany, SusanaEntity
UAM. Departamento de Farmacología; UAM. Departamento de Fisiología; UAM. Departamento de MedicinaPublisher
American Association for the Advancement of ScienceDate
2022-04-06Citation
10.1126/sciadv.abj7110
Science Advances 8.14 (2022): 7110
ISSN
2375-2548 (online)DOI
10.1126/sciadv.abj7110Editor's Version
https://doi.org/10.1126/sciadv.abj7110Subjects
Malaria; Brain; Hypothyroidism; Mice; Thyroid hormones; MedicinaRights
© 2022 The AuthorsAbstract
The modulation of the host’s metabolism to protect tissue from damage induces tolerance to infections increasing survival. Here, we examined the role of the thyroid hormones, key metabolic regulators, in the outcome of malaria. Hypothyroidism confers protection to experimental cerebral malaria by a disease tolerance mechanism. Hypothyroid mice display increased survival after infection with Plasmodium berghei ANKA, diminishing intracranial pressure and brain damage, without altering pathogen burden, blood-brain barrier disruption, or immune cell infiltration. This protection is reversed by treatment with a Sirtuin 1 inhibitor, while treatment of euthyroid mice with a Sirtuin 1 activator induces tolerance and reduces intracranial pressure and lethality. This indicates that thyroid hormones and Sirtuin 1 are previously unknown targets for cerebral malaria treatment, a major killer of children in endemic malaria areas
Files in this item
Google Scholar:Rodriguez-Muñoz, Diego
-
Sánchez, Ángela
-
Pérez-Benavente, Susana
-
Contreras-Jurado, Constanza
-
Montero-Pedrazuela, Ana
-
Toledo-Castillo, Marta
-
Gutiérrez-Hernández, María
-
Rodrigues Díez, Raquel
-
Folgueira, Cintia
-
Briones, Ana M.
-
Sabio, Guadalupe
-
Monedero-Cobeta, Ignacio
-
Chávez-Coira, Irene
-
Castejón, David
-
Fernández-Valle, Encarnación
-
Regadera González, Javier Fco.
-
Bautista, José M.
-
Aranda, Ana
-
Alemany, Susana
This item appears in the following Collection(s)
- Producción científica de la UAM [20783]
Related items
Showing items related by title, author, creator and subject.
-
The thyroid hormone receptors inhibit hepatic interleukin-6 signaling during endotoxemia
Contreras-Jurado, Constanza; Alonso-Merino, Elvira; Saiz-Ladera, Cristina; Valiño, Arturo José; Regadera, Javier; Alemany, Susana; Aranda, Ana
2016-08-03 -
Stress erythropoiesis in atherogenic mice
Sánchez, Ángela; Orizaola, Marta C.; Rodríguez-Muñoz, Diego; Aranda, Ana; Castrillo, Antonio; Alemany, Susana
2020-10-28