Is iPS cell the panacea?
Creator
Ou, Li
Wang, Xiaochen
Zou, Fangdong
Bibliographic Citation
IUBMB life 2010 Mar ; 62(3): 170-5
Abstract
In 2006, it was reported that transgenic expression of merely four defined transcription factors (c-Myc, Klf4, Oct4, and Sox2) is sufficient to reprogram somatic cells to a pluripotent state. The resulting induced pluripotent stem (iPS) cells ignited intense interest in the field of life science for their promising applications in basic biology, drug development, and transplantation. However, the underlying problems of iPS cells seem to be ignored. This review shed light on the problems pertaining iPS cells, including the elusive origin, risk of tumorgenesis, and its relationship with natural selection.
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http://hdl.handle.net/10822/515401External Link
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Is iPS cell the panacea?
Ou, Li; Wang, Xiaochen; Zou, Fangdong (2010-03)In 2006, it was reported that transgenic expression of merely four defined transcription factors (c-Myc, Klf4, Oct4, and Sox2) is sufficient to reprogram somatic cells to a pluripotent state. The resulting induced pluripotent ...