Please use this identifier to cite or link to this item:
https://hdl.handle.net/11147/5365
Title: | The Prognostic Value of Tumor-Stroma Proportion in Laryngeal Squamous Cell Carcinoma |
Other Titles: | Laringeal skuamöz hücreli karsinomlarda tümör-stroma oranının prognostik değeri |
Authors: | Ünlü, Mehtat Çetinayak, Hasan Oğuz Önder, Devrim Ecevit, Cenk Akman, Fadime İkiz, Ahmet ömer Ada, Emel Karaçalı, Bilge Sarıoğlu, Sülen |
Keywords: | Tumor Laryngeal neoplasms Prognosis Stromal cell |
Publisher: | Federation of Turkish Pathology Societies |
Source: | Ünlü, M., Çetinayak, H. O., Önder, D., Ecevit, C., Akman, F., İkiz, A. Ö., Ada, E., Karaçalı, B., and Sarıoğlu, S. (2013). The prognostic value of tumor-stroma proportion in laryngeal squamous cell carcinoma. Turkish Journal of Pathology, 29(1). 27-35. doi:10.5146/tjpath.2013.01144 |
Abstract: | Objective: Tumor-stroma proportion of tumor has been presented as a prognostic factor in some types of adenocarcinomas, but there is no information about squamous cell carcinomas and laryngeal carcinomas. Material and Method: Five digital images of the tumor sections were obtained from 85 laryngeal carcinomas. Proportion of epithelial tumor component and stroma were measured by a software tool, allowing the pathologists to mark 205.6 μm2 blocks on areas as carcinomatous/stromal, by clicking at the image. Totally, 3.451 mm2 tumor areas have been marked to 16.785 small square blocks for each case. Results: Median follow up was 48 months (range 3-194). The mean tumor-stroma proportion was 48.63+18.18. There was no difference for tumor-stroma proportion when tumor location, grade, stage and perinodal invasion were considered. Although the following results were statistically insignificant, the mean tumor-stroma proportion was the lowest (37.46±12.49) for subglottic carcinomas, and it was 52.41±37.47, 50.86+19.84 and 44.56±16.91 for supraglottic, transglottic and glottic cases. The tumor-stroma proportion was lowest in cases with perinodal invasion and the highest in cases without lymph node metastasis (44.72±20.23, 47.77±17.37, 50.05±17.34). Tumor-stroma proportion was higher in the basaloid subtype compared with the classical squamous cell carcinoma (53.76±14.70 and 48.63±18.38 respectively). The overall and disease-free survival analysis did not reveal significance for tumor-stroma proportion (p=0.08, p=0.38). Only pathological stage was an independent factor for overall survival (p=0.008). Conclusion: This is the first series investigating tumor-stroma proportion as a prognostic marker in laryngeal carcinomas proposing a new method, but the findings do not support tumor-stroma proportion as a prognostic marker. |
URI: | http://doi.org/10.5146/tjpath.2013.01144 http://hdl.handle.net/11147/5365 https://search.trdizin.gov.tr/yayin/detay/159519 |
ISSN: | 1018-5615 1309-5730 |
Appears in Collections: | Electrical - Electronic Engineering / Elektrik - Elektronik Mühendisliği PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection TR Dizin İndeksli Yayınlar / TR Dizin Indexed Publications Collection |
Show full item record
CORE Recommender
Items in GCRIS Repository are protected by copyright, with all rights reserved, unless otherwise indicated.