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    • Proszę używać tego identyfikatora do cytowań lub wstaw link do tej pozycji: http://hdl.handle.net/11320/15006
    Tytuł: Biologically Active Compounds of Plants: Structure-Related Antioxidant, Microbiological and Cytotoxic Activity of Selected Carboxylic Acids
    Autorzy: Beata Godlewska-Żyłkiewicz, Beata
    Świsłocka, Renata
    Kalinowska, Monika
    Golonko, Aleksandra
    Świderski, Grzegorz
    Arciszewska, Żaneta
    Nalewajko-Sieliwoniuk, Edyta
    Naumowicz, Monika
    Lewandowski, Włodzimierz
    Słowa kluczowe: 
    phenolic acids,
    natural carboxylic acids,
    structure-activity relationship,
    hydroxyl groups,
    antibacterial,
    antioxidant,
    cytotoxic activity
    Data wydania: 2020
    Data dodania: 24-maj-2023
    Wydawca: MDPI
    Źródło: Materials, Volume 13 Issue 19 (2020), p. 1-37
    Abstrakt: Natural carboxylic acids are plant-derived compounds that are known to possess biological activity. The aim of this review was to compare the effect of structural differences of the selected carboxylic acids (benzoic acid (BA), cinnamic acid (CinA), p-coumaric acid (p-CA), caffeic acid (CFA), rosmarinic acid (RA), and chicoric acid (ChA)) on the antioxidant, antimicrobial, and cytotoxic activity. The studied compounds were arranged in a logic sequence of increasing number of hydroxyl groups and conjugated bonds in order to investigate the correlations between the structure and bioactivity. A review of the literature revealed that RA exhibited the highest antioxidant activity and this property decreased in the following order: RA > CFA ~ ChA > p-CA > CinA > BA. In the case of antimicrobial properties, structure-activity relationships were not easy to observe as they depended on the microbial strain and the experimental conditions. The highest antimicrobial activity was found for CFA and CinA, while the lowest for RA. Taking into account anti-cancer properties of studied NCA, it seems that the presence of hydroxyl groups had an influence on intermolecular interactions and the cytotoxic potential of the molecules, whereas the carboxyl group participated in the chelation of endogenous transition metal ions.
    Afiliacja: Beata Godlewska-Żyłkiewicz - Department of Analytical Chemistry, Faculty of Chemistry, University of Bialystok
    Renata Świsłocka - Department of Chemistry, Biology and Biotechnology, Bialystok University of Technology
    Monika Kalinowska - Department of Chemistry, Biology and Biotechnology, Bialystok University of Technology
    Aleksandra Golonko - Institute of Agricultural and Food Biotechnology, Warsaw
    Grzegorz Świderski - Department of Chemistry, Biology and Biotechnology, Bialystok University of Technology
    Żaneta Arciszewska - Department of Analytical Chemistry, Faculty of Chemistry, University of Bialystok
    Edyta Nalewajko-Sieliwoniuk - Department of Analytical Chemistry, Faculty of Chemistry, University of Bialystok
    Monika Naumowicz - Department of Physical Chemistry, Faculty of Chemistry, University of Bialystok
    Włodzimierz Lewandowski - Department of Chemistry, Biology and Biotechnology, Bialystok University of Technology
    Sponsorzy: This work was financially supported by National Science Centre, Poland, under the research project number 2018/29/B/NZ9/01997.
    URI: http://hdl.handle.net/11320/15006
    DOI:10.3390/ma13194454
    ISSN: 1996-1944
    ORCID ID:0000-0002-2576-4029 - Beata Godlewska-Żyłkiewicz, Beata
    0000-0001-7034-9126 - Świsłocka, Renata
    0000-0002-0839-9891 - Kalinowska, Monika
    brakORCID - Golonko, Aleksandra
    0000-0003-4442-6348 - Świderski, Grzegorz
    0000-0001-9307-8146 - Arciszewska, Żaneta
    0000-0003-3416-0371 - Nalewajko-Sieliwoniuk, Edyta
    0000-0001-5229-1805 - Naumowicz, Monika
    brakORCID - Lewandowski, Włodzimierz
    Typ Dokumentu: Article
    metadata.dc.rights.uri: http://creativecommons.org/licenses/by/4.0/
    Właściciel praw: © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license
    Występuje w kolekcji(ach):Artykuły naukowe (WChem)

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