Publication: Acute bacterial cystitis does not cause deoxyribonucleic acid damage detectable by the alkaline comet assay in urothelial cells of dogs
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Date
2004-05-01
Advisor
Coadvisor
Graduate program
Undergraduate course
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Volume Title
Publisher
Amer Coll Vet Pathologist
Type
Article
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Acesso restrito
Abstract
Considering the high incidence of dogs with acute bacterial cystitis (BC) and the relationship among inflammation, genotoxicity, and carcinogenesis, we conducted a case-control study comparing the frequency of deoxyribonucleic acid (DNA) lesions assessed by the comet assay between disease-free animals (13 males and 13 females) and cytology-confirmed cases of acute BC (12 males and 12 females), which was mainly caused by Staphylococcus sp. (40%) and Escherichia coli (35%). The results show no increase in DNA damage in cells obtained by bladder washings and no influence of age, sex, and breed due to acute BC. In conclusion, DNA damage was seemingly not associated with the infection by specific bacteria.
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Language
English
Citation
Veterinary Pathology. Lawrence: Amer Coll Vet Pathologist, v. 41, n. 3, p. 299-301, 2004.
