Treatment of experimental periodontitis with chlorhexidine as adjuvant to scaling and root planing
Nenhuma Miniatura disponível
Data
2020-02-01
Título da Revista
ISSN da Revista
Título de Volume
Editor
Elsevier B.V.
Resumo
Objectives: To assess whether subgingival irrigation with 0.12 % or 0.2 % chlorhexidine (CHX) immediately after scaling and root planing (SRP) enhances periodontal tissue repair compared to irrigation with saline solution (control). Materials and methods: Periodontitis was ligature-induced in rat molars for 7 days. Animals were distributed into three groups: 1) SRP group, SRP and irrigation with 0.9 % saline (n = 30); 2) SRP + 0.12 % CHX group, SRP and irrigation with 0.12 % CHX (n = 30); 3) SRP + 0.2 % CHX group, SRP and irrigation with 0.2 % CHX (n = 30). Animals were killed at 7, 15, and 30 days after treatment. Furcation region was histometrically analyzed to determine the bone area. Immunohistochemical reactions were performed for receptor activator of nuclear factor-kB ligand (RANKL), osteoprotegerin (OPG) and tartrate-resistant acid phosphatase (TRAP). Results: Both chlorhexidine groups presented less inflammation and improved tissue repair along the entire experiment when compared with the SRP group. In the histometric analysis at 7, 15 and 30 days, SRP group (4.58 +/- 2.51 mm2, 4.21 +/- 1.25 mm2, 3.49 +/- 1.48 mm2), showed statistically less bone area than groups SRP + 0.12 % CHX (1.86 +/- 1.11 mm(2) ; 0.79 +/- 0.27 mm(2) ; 0.34 +/- 0.14 mm(2)) and SRP + 0.2 % CHX (1.14 +/- 0.51 mm(2); 0.98 +/- 0.40 mm(2) ; 0.41 +/- 0.21 mm(2)). Both chlorhexidine concentrations modulated the expression of TRAP, RANKL and OPG. Conclusions: Subgingival irrigation with chlorhexidine contributed for a quicker shift from a proinflammatory destructive profile to healing of periodontal tissues.
Descrição
Palavras-chave
Periodontitis, Periodontal diseases, Rats, Wound healing, Dental scaling, Chlorhexidine
Como citar
Archives Of Oral Biology. Oxford: Pergamon-elsevier Science Ltd, v. 110, 6 p., 2020.