Respostas fisiológicas ao exercício agudo em ratos obesos tratados com metformina
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Data
2007-12-01
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Editor
Sociedade Brasileira de Medicina do Exercício e do Esporte
Resumo
O objetivo do presente estudo foi investigar as respostas fisiológicas ao exercício agudo em ratos Wistar obesos, tratados com metformina. Os animais receberam injeção subcutânea de glutamato monossódico (4mg/g peso corporal), para indução da obesidade. Os animais foram divididos em 4 grupos, conforme o tratamento recebido: obesos controles (OC); obesos metformina (OM); obesos controles exercitados (OCE) e obesos metformina exercitados (OME). Foram analisados, antes e após uma sessão de exercício agudo: glicose sérica (mg/dL), triglicerídeos (g/100g), colesterol total (mg/dL) e hematócrito (%). Os valores de glicose sérica e colesterol total foram reduzidos significativamente no grupo controle exercitado (OCE - 68,4 ± 14,7 e 70,8 ± 18,3) em comparação ao grupo controle sedentário (OC - 83,6 ± 12,8 e 91,3 ± 9,6). A administração de metformina isoladamente diminuiu a concentração de glicose de 83,6 ± 12,8 (OC) para 70,8 ± 5,9 (OM). Por outro lado, a associação de metformina com exercício aumentou a disponibilidade de triacilgliceróis livres após a atividade (OM - 166,6 ± 11,3, OME - 184,0 ± 4,3). em conclusão o programa de intervenção utilizado (exercício físico agudo) mostrou-se eficiente na homeostasia glicêmica, bem como, nos níveis circulantes de lipídios em ratos obesos tratados com metformina.
The purpose of the present study was to investigate the physiological responses to intense exercise in obese Wistar rats treated with metformin. To induce obesity, all animals were infused with monosodic glutamate (4 mg/g of body weight) via subcutaneous injection. The rats were divided in 4 groups according to the received treatment: obese control (OC); obese metformin ( OM); obese control exercise (OCE) and obese metformin exercise (OME). Before and after one session of intense exercise the following parameters were measured: serum glucose (mg/dl), triglycerides (g/100g), total cholesterol (mg/dl) and haematocrit (%). The values of serum glucose and total cholesterol were significantly reduced in control exercise group (OCE - 68.4 ± 14.7 and 70.8 ±18.3) compared to obese control sedentary group (OC - 83.6 ± 12.8 and 91.3 ± 9.6). The isolate metformin infusion decreased the glucose concentration from 83.6 ± 12.8 (OC) to 70.8 ± 5.9 (OM). on the other hand, metformin associated with exercise increased the availability of free triglycerides after exercise (OM - 166.6 ± 11.3, OME - 184.0 ± 4.3). In conclusion, the present intervention program (intense physical exercise) showed to be efficient on glicemic homeostasis, as well as on lipids circulatory levels in obese rats treated with metformin.
The purpose of the present study was to investigate the physiological responses to intense exercise in obese Wistar rats treated with metformin. To induce obesity, all animals were infused with monosodic glutamate (4 mg/g of body weight) via subcutaneous injection. The rats were divided in 4 groups according to the received treatment: obese control (OC); obese metformin ( OM); obese control exercise (OCE) and obese metformin exercise (OME). Before and after one session of intense exercise the following parameters were measured: serum glucose (mg/dl), triglycerides (g/100g), total cholesterol (mg/dl) and haematocrit (%). The values of serum glucose and total cholesterol were significantly reduced in control exercise group (OCE - 68.4 ± 14.7 and 70.8 ±18.3) compared to obese control sedentary group (OC - 83.6 ± 12.8 and 91.3 ± 9.6). The isolate metformin infusion decreased the glucose concentration from 83.6 ± 12.8 (OC) to 70.8 ± 5.9 (OM). on the other hand, metformin associated with exercise increased the availability of free triglycerides after exercise (OM - 166.6 ± 11.3, OME - 184.0 ± 4.3). In conclusion, the present intervention program (intense physical exercise) showed to be efficient on glicemic homeostasis, as well as on lipids circulatory levels in obese rats treated with metformin.
Descrição
Palavras-chave
Metformina, Obesidade, Natação, Metformin, Obesity, Swimming
Como citar
Revista Brasileira de Medicina do Esporte. Sociedade Brasileira de Medicina do Exercício e do Esporte, v. 13, n. 6, p. 393-396, 2007.