New Palladium(II) Complexes Containing Methyl Gallate and Octyl Gallate: Effect against Mycobacterium tuberculosis and Campylobacter jejuni
Nenhuma Miniatura disponível
Data
2023-05-01
Autores
Silva, Raphael Tristão Cruvinel
Guidotti-Takeuchi, Micaela
Peixoto, Jéssica Laura Miranda
Demarqui, Fernanda Manaia [UNESP]
Mori, Ananda Paula
Dumont, Carolyne Ferreira
Ferreira, Gabriella Rayane Aparecida
Pereira, Gabriele de Menezes
Rossi, Daise Aparecida
Corbi, Pedro Paulo
Título da Revista
ISSN da Revista
Título de Volume
Editor
Resumo
This work describes the preparation, characterization and antimicrobial activity of four palladium(II) complexes, namely, [Pd(meg)(1,10-phen)] 1, [Pd(meg)(PPh3)2] 2, [Pd(og)(1,10-phen)] 3 and [Pd(og)(PPh3)2] 4, where meg = methyl gallate, og = octyl gallate, 1,10-phen = 1,10-phenanthroline and PPh3 = triphenylphosphine. As to the chemical structures, spectral and physicochemical studies of 1–4 indicated that methyl or octyl gallate coordinates a palladium(II) ion through two oxygen atoms upon deprotonation. A chelating bidentate phenanthroline or two triphenylphosphine molecules complete the coordination sphere of palladium(II) ion, depending on the complex. The metal complexes were tested against the Mycobacterium tuberculosis H37Rv strain and 2 exhibited high activity (MIC = 3.28 μg/mL). As to the tests with Campylobacter jejuni, complex 1 showed a significant effect in reducing bacterial population (greater than 7 log CFU) in planktonic forms, as well as in the biomass intensity (IBF: 0.87) when compared to peracetic acid (IBF: 1.11) at a concentration of 400 μg/mL. The effect provided by these complexes has specificity according to the target microorganism and represent a promising alternative for the control of microorganisms of public health importance.
Descrição
Palavras-chave
anti-infective drugs, antibacterial activity, Campylobacter jejuni, Mycobacterium tuberculosis, palladium(II) complexes
Como citar
Molecules, v. 28, n. 9, 2023.