Publication: Synthesis, characterization and initial biological studies of a new platinum(II) complex with deoxyalliin
Loading...
Date
Advisor
Coadvisor
Graduate program
Undergraduate course
Journal Title
Journal ISSN
Volume Title
Publisher
Taylor & Francis Ltd
Type
Article
Access right
Acesso restrito
Abstract
A new platinum(II) complex with deoxyalliin was synthesized and characterized by chemical and spectroscopic techniques. Elemental and mass spectrometry analyses of the solid complex fit to the composition [Pt(C6H11NO2S)Cl-2] center dot H2O. C-13 NMR, N-15 NMR and infrared spectra of the complex are consistent with coordination of deoxyalliin to Pt( II) through the nitrogen and sulfur atoms forming a square-planar geometry. The complex is soluble in dimethylsulfoxide. Biological analysis for evaluation of a potential cytotoxic effect of the complex was performed using HeLa cells, a human cervix adenocarcinoma-derived cell line. The results were compared with those of a palladium( II) complex previously described.
Description
Keywords
platinum(II), deoxyalliin, N-15 NMR, cancer therapy
Language
English
Citation
Journal of Coordination Chemistry. Abingdon: Taylor & Francis Ltd, v. 59, n. 10, p. 1101-1106, 2006.
