Publication: Liver response to low-hexachlorobenzene exposure in protein- or energy-restricted rats
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Date
1991-12-01
Advisor
Coadvisor
Graduate program
Undergraduate course
Journal Title
Journal ISSN
Volume Title
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Type
Article
Access right
Acesso restrito
Abstract
The individual effects of protein deficiency and energy restriction on liver response to low-hexachlorobenzene (HCB) exposure were investigated in adult male Wistar rats. In rats fed either the low-protein or control diet, the only effect caused by HCB was a decrease in paralysis time following an ip injection of zoxazolamine. This decrease was similar for both groups. In the animals subjected to energy restriction, HCB induced a greater decrease in paralysis time, an increase in the size of centrilobular hepatocytes, a lower liver DNA content and an increased concentration of HCB in the adipose tissue, compared with the control and protein-deficient groups. Our data suggest that energy restriction increases liver response to HCB, while protein deficiency does not impair the hepatic reaction to small doses of HCB exposure.
Description
Keywords
hexachlorobenzene, adipose tissue, animal experiment, energy, liver toxicity, male, nonhuman, paralysis, priority journal, protein deficiency, rat, Administration, Oral, Animal, Body Weight, Dietary Proteins, Energy Intake, Hexachlorobenzene, Liver, Male, Organ Weight, Paralysis, Rats, Rats, Inbred Strains, Support, Non-U.S. Gov't, Tissue Distribution
Language
English
Citation
Food and Chemical Toxicology, v. 29, n. 11, p. 757-764, 1991.
