Antibacterial activity of a stearic acid derivative from Stemodia foliosa
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Abstract
From the hexane-soluble fraction of an ethanol extract from leaves and stems of Stemodia foliosa (Scrophulariaceae), the new stearic acid 4-[(n-pentoxy)phenethyl] ester (1) was isolated. This compound exhibited antibacterial properties at 10μg/mL concentration by using disc diffusion method against Gram-positive bacteria Bacillus cereus and Bacillus subtilis and fast-acid bacterium Mycobacterium fortuitum. The structure of the new compound was elucidated by spectroscopic methods and by chemical conversion.
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Keywords
4 [(n pentoxy)phenethyl] ester, alcohol, clarithromycin, ester, hexane, plant extract, stearic acid derivative, unclassified drug, acid fast bacterium, antibacterial activity, Bacillus subtilis, controlled study, Gram positive bacterium, Mycobacterium fortuitum, nuclear magnetic resonance spectroscopy, plant leaf, plant stem, Scrophulariaceae, Anti-Bacterial Agents, Bacteria, Clarithromycin, Magnetic Resonance Spectroscopy, Molecular Structure, Plant Extracts, Plant Leaves, Plant Stems, Stearates, Stearic Acids, Actinobacteria (class), Bacillus cereus, Bacteria (microorganisms), Mycobacterium, Posibacteria, Stemodia, uncultured actinomycete
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English
Citation
Planta Medica, v. 68, n. 12, p. 1137-1139, 2002.
