Perinatal exposure to parasiticide ivermectin: Long-term effects on reproductive parameters of adult male rats
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Data
2011-02-01
Autores
Terneux, Eduardo Wladimir Avilés [UNESP]
Pontes, Davi Abeid
Fernandez, Carla Dal Bianco
Arena, Arielle Cristina
Porto, Elaine Manoela
de Kempinas, Wilma Grava [UNESP]
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Resumo
Ivermectin is one of the most widely used antiparasitic drugs globally. The aim of this study was to evaluate the chronic effects of perinatal exposure to ivermectin on male reproductive parameters in rats. Pregnant rats were treated daily by oral gavage with 0.4 or 1.6 mg kg -1 of ivermectin or vehicle, from gestational day 6 until post-natal day 10. In the adulthood stage, there were significant reductions in the relative testicular weight of rats exposed to the low dose and in relative prostate weight of male rats exposed to the high dose of ivermectin. Furthermore, the animals exposed to the low dose also presented an increased seminal vesicle weight compared to controls. However, neither of the ivermectin doses interfered in daily sperm production, sperm number in testis, or sexual behavior of exposed males. In conclusion, perinatal exposure to ivermectin neither altered the male reproductive system development markedly, nor produced any adverse effects on the parameters evaluated. © 2011 Taylor & Francis.
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Palavras-chave
Gestation, Ivermectin, Male reproductive system, Parasiticide, Rat, Adverse effect, Antiparasitic drugs, Chronic effects, High dose, Long-term effects, Low dose, Male rats, Pregnant rat, Reproductive systems, Seminal vesicle, Animals, Rats, developmental biology, dose-response relationship, ivermectin, male, pollution effect, pollution exposure, pregnancy, reproductive strategy, rodent, secondary sexual characteristics, sperm, Animalia, Rattus
Como citar
Toxicological and Environmental Chemistry, v. 93, n. 2, p. 345-351, 2011.