Gastrointestinal cytomegalovirus disease in renal transplant recipients: A case series
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Data
2012-03-01
Autores
de Andrade, Luís G.M. [UNESP]
Rodrigues, Maria A.M. [UNESP]
Romeiro, Fernando Gomes [UNESP]
Carvalho, Maria F.C. [UNESP]
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Resumo
The purpose of this article was to report a series of 23 renal transplant recipients with histologically proven and immunohistochemically confirmed cytomegalovirus (CMV) lesions in the gastrointestinal tract (GIT) and to assess the risk factors associated with severe disease/mortality. CMV patients (n=23) were allocated into two groups: those who died (n=6) and those considered cured (n=17). Overall mortality rate was 26% (6/23). Initial symptoms suggestive of lower GIT involvement were observed in all death cases and in 35.3% of those cured (p=0.01). Enterorrhagia was seen in 83.3% of the patients who died. Death risk increased twofold (RR 2 [1.13-3.52], p=0.01) when symptoms of lower GIT involvement were initially observed and sixfold when enterrohagia was present (RR 6 [1.1-35.9], p=0.001). Among death cases, mean time at diagnosis was significantly more distant (2002±2.9×2008±1.6, p=0.04). The difference in mortality rates seen as service practices changed along the years demonstrates the importance of early diagnosis. © 2011 John Wiley & Sons A/S.
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Cytomegalovirus, Gastrointestinal, Renal transplantation, adult, cytomegalovirus infection, female, gastrointestinal infection, graft recipient, histopathology, human, human tissue, immunohistochemistry, intestinal bleeding, kidney transplantation, major clinical study, male, mortality, priority journal, risk assessment, symptom, Adult, Cytomegalovirus Infections, Female, Gastrointestinal Diseases, Humans, Immunocompromised Host, Kidney Transplantation, Male, Middle Aged, Opportunistic Infections, Risk Factors
Como citar
Clinical Transplantation, v. 26, n. 2, p. 345-350, 2012.