Avaliação da remodelação óssea após a interrupção do tratamento com bifosfonato por um período prolongado e seu efeito sobre a osseointegração
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Data
2012-03-16
Autores
Borges Filho, Fausto Frizzera [UNESP]
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Editor
Universidade Estadual Paulista (Unesp)
Resumo
O objetivo deste estudo foi avaliar as alterações no processo de remodelação óssea após a suspensão do tratamento com alendronato e sua influência sobre a osseointegração de implantes. Para isso, setenta ratas Wistar foram divididas em 2 grupos que receberam no dia 0 placebo (grupo controle-CTLE, n = 10) ou alendronato, na dose de 1 mg/kg (grupo teste, n = 60), uma vez por semana, por 120 dias. No dia 120 o tratamento com alendronato foi interrompido em 50 animais. Um implante de titânio foi instalado na metáfise tibial esquerda nos dias 0, 7, 14, 28 e 45 dias após a interrupção do tratamento (n=10 em cada período). O grupo CTLE e um grupo que continuou a receber o alendronato até o fim do experimento (grupo ininterrupto – INT, n=10) foram submetidos à cirurgia para instalação do implante no dia 120. Todos animais foram sacrificados 28 dias após a instalação dos implantes. Foram avaliados a densidade mineral óssea do fêmur e das vértebras lombares, os marcadores bioquímicos de remodelação óssea osteocalcina (OCN), propeptídeo aminoterminal do colágeno tipo I (P1NP), telopeptídeo carboxiterminal do colágeno tipo I (CTX) no dia da instalação do implante e no dia do sacrifício. O tecido ósseo ao redor dos implantes foi analisado de forma descritiva, e por meio da avaliação da quantidade de tecido ósseo em contato com a superfície do implante (BIC) e da área de tecido ósseo presente entre as roscas do implante (BAFO). Todos os grupos submetidos ao tratamento com alendronato apresentaram valores de densidade óssea significativamente maiores quando comparados ao grupo CTLE. Os marcadores de remodelação óssea apresentaram concentrações séricas menores no grupo teste, sendo que após a suspensão do tratamento com alendronato observou-se discreto aumento nos períodos...
The aim of this study was to evaluate bone turnover alterations after alendronate withdrawal and its influence on dental implants osseointegration. Seventy female Wistar rats were divided in 2 groups that received on day 0 either placebo (control group – CTLE, n = 10) or alendronate 1mg/kg (test group, n = 60) once a week for 120 days. At day 120 alendronate treatment was suspended for 50 animals. A titanium implant was placed in rats’ left tibiae on days 0, 7, 14, 28 and 45 after alendronate withdrawal (n=10 for each period). CTLE group and a group that received alendronate until the end of the experimental period (non interrupted group - INT, n = 10) underwent implant placement surgery on day 120. All animals were euthanized 28 days after implant surgery. Bone mineral density (BMD) of femur and lumbar vertebrae and biochemical markers of bone turnover of serum collected on implant placement surgery’s and euthanization’s days were analyzed. Bone tissue around implants was submitted to descriptive analysis, bone-to-implant contact (BIC) and bone area fraction occupancy between implant threads (BAFO). All groups receiving alendronate showed higher BMD values when compared to CTLE group. Bone turnover markers presented decreased concentrations in test group. After alendronate withdrawal these values were slightly increased in the initials periods followed by another decrease in biomarkers concentrations in the late periods. No difference was 17 observed between groups for the BIC ratio. However group 45 days BAFO were statically significant lower than group 0 day. Although there was not difference in the bone quantity around implants, its quality was apparently compromised in the groups that received alendronate. The findings of this study demonstrated that alendronate... (Complete abstract click electronic access below)
The aim of this study was to evaluate bone turnover alterations after alendronate withdrawal and its influence on dental implants osseointegration. Seventy female Wistar rats were divided in 2 groups that received on day 0 either placebo (control group – CTLE, n = 10) or alendronate 1mg/kg (test group, n = 60) once a week for 120 days. At day 120 alendronate treatment was suspended for 50 animals. A titanium implant was placed in rats’ left tibiae on days 0, 7, 14, 28 and 45 after alendronate withdrawal (n=10 for each period). CTLE group and a group that received alendronate until the end of the experimental period (non interrupted group - INT, n = 10) underwent implant placement surgery on day 120. All animals were euthanized 28 days after implant surgery. Bone mineral density (BMD) of femur and lumbar vertebrae and biochemical markers of bone turnover of serum collected on implant placement surgery’s and euthanization’s days were analyzed. Bone tissue around implants was submitted to descriptive analysis, bone-to-implant contact (BIC) and bone area fraction occupancy between implant threads (BAFO). All groups receiving alendronate showed higher BMD values when compared to CTLE group. Bone turnover markers presented decreased concentrations in test group. After alendronate withdrawal these values were slightly increased in the initials periods followed by another decrease in biomarkers concentrations in the late periods. No difference was 17 observed between groups for the BIC ratio. However group 45 days BAFO were statically significant lower than group 0 day. Although there was not difference in the bone quantity around implants, its quality was apparently compromised in the groups that received alendronate. The findings of this study demonstrated that alendronate... (Complete abstract click electronic access below)
Descrição
Palavras-chave
Periodontia, Osseointegração, Marcadores biologicos
Como citar
BORGES FILHO, Fausto Frizzera. Avaliação da remodelação óssea após a interrupção do tratamento com bifosfonato por um período prolongado e seu efeito sobre a osseointegração. 2012. 117 f. Dissertação (mestrado) - Universidade Estadual Paulista - Faculdade de Odontologia de Araraquara, 2012.