Role of central arginine vasopressin receptors in the analgesic effect of CDP-choline on acute and neuropathic pain
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Tarih
2013-12-04
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Yayınevi
Lippincott Williams and Wilkins
Özet
Recent studies have demonstrated that arginine vasopressin (AVP) plays a crucial role in pain modulation. In addition, our previous studies have proven that centrally administered cytidine-5-diphosphate-choline (CDP-choline; citicoline) elicits an analgesic effect in different pain models in rats. Given that CDP-choline enhances central and peripheral vasopressin levels, the present study was designed to investigate the role of central AVP receptors in the analgesic effect of CDP-choline in acute and chronic constriction injury-induced neuropathic pain models. For this purpose, rats were pretreated intracerebroventricularly with the AVP V-1 or AVP V-2 receptor antagonist 15 min before intracerebroventricular injection of CDP-choline or saline, and pain threshold was determined using the Randall-Selitto test. AVP V-1 and AVP V-2 receptor antagonist blocked the CDP-choline-induced analgesic effect either in acute or neuropathic models of pain in rats. These results suggest, for the first time, that central AVP receptors are involved in the CDP-choline-elicited analgesic effect.
Açıklama
Anahtar kelimeler
Neurosciences & neurology, Acute pain, Analgesia, Arginine vasopressin, CDP-choline, Neuropathic pain, Periaqueductal gray, Antinociception, Rat, Involvement, Nociception, Nuclei, Models
Alıntı
Bağdaş, D. vd. (2013). “Role of central arginine vasopressin receptors in the analgesic effect of CDP-choline on acute and neuropathic pain”. Neuroreport, 24(17), 941-946.