Interleukin-6 inhibitors reduce mortality in coronavirus disease-2019: An individual patient data meta-analysis from randomized controlled trials
Ημερομηνία
2022Γλώσσα
en
Λέξη-κλειδί
Επιτομή
Objective: To assess the efficacy of IL-6 inhibitors compared to standard of care (SOC) in COVID-19 patients. Data Sources: A systematic review of the MEDLINE and Scopus databases (last search: October 8th, 2021) was performed according to the PRISMA statement. Study Selection: Randomized control trials (RCTs) comparing IL-6 inhibitors to SOC in hospitalized COVID-19 patients were deemed eligible. Data Extraction and Synthesis: Individual patient data were extracted from the Kaplan-Meier curves or were obtained from authors of included studies. Additionally, the reviewers independently abstracted data and assessed study quality of each eligible report. Results: Eleven studies were identified, incorporating 7467 patients (IL-6 inhibitors: 4103, SOC: 3364). IL-6 inhibitors were associated with decreased risk for death compared to SOC at the one-stage meta-analysis (Hazard Ratio [HR]: 0.75, 95% Confidence interval [CI]: 0.69–0.82, p<0.0001) and the two-stage meta-analysis (HR: 0.85, 95%CI: 0.77–0.93, p<0.001, I2 = 0.0%). Meta-regression analysis revealed that the difference in OS between the two groups was not influenced by the mean age of patients. At secondary meta-analyses, IL-6 inhibitors were associated with decreased odds for intubation OR:0.74, 95%CI:0.65–0.85, p<0.001, I2=0.0%). IL-6 inhibitors were associated with increased odds for discharge compared to SOC (OR:1.28, 95% CI:1.15–1.42, p<0.001, I2=0.0%). Conclusions and Relevance: This meta-analysis of individual patient data from randomized trials shows that IL-6 inhibitors significantly reduce the risk of death compared to SOC. IL-6 inhibitors are also associated with better outcomes in terms of intubation and discharge rates compared to SOC. © 2022
Collections
Related items
Showing items related by title, author, creator and subject.
-
Skeletal muscle relaxants in anaesthesiology
Benakis, A.; Plessas, C. T.; Plessas, S. T. (1999)During the 16th century, European explorers found that the Indians along the Amazon and Orinoco Rivers were using an arrow poison, named curare, that produced death by skeletal paralysis. Curare is one of several different ... -
Chios mastic gum: A plant-produced resin exhibiting numerous diverse pharmaceutical and biomedical prοperties
Dimas, K. S.; Pantazis, P.; Ramanujam, R. (2012)Chios mastic gum (CMG) is a resin produced by the plant Pistacia lentiscus var. chia. CMG is used to extract the mastic gum essential oil (MGO). CMG and MGO consist of nearly 70 constituents and have demonstrated numerous ... -
Drug-induced endocrinopathies and diabetes: A combo-endocrinology overview
Diamanti-Kandarakis E., Duntas L., Kanakis G.A., Kandaraki E., Karavitaki N., Kassi E., Livadas S., Mastorakos G., Migdalis I., Miras A.D., Nader S., Papalou O., Poladian R., Popovic V., Rachoń D., Tigas S., Tsigos C., Tsilchorozidou T., Tzotzas T., Bargiota A., Pfeifer M., on behalf of COMBO ENDO TEAM: 2018 (2019)In the currently overwhelming era of polypharmacy, the balance of the dynamic and delicate endocrine system can easily be disturbed by interfering pharmaceutical agents like medications. Drugs can cause endocrine abnormalities ...