Variation in the attachment of Streptococcus pneumoniae to human pharyngeal epithelial cells after treatment with S-carboxymethylcysteine
Date
2008
Authors
Suer, E.
Sayrac, S.
Sarinay, E.
Ozturk H.E.
Turkoz, M.
Ichinose, A.
Nagatake, T.
Ahmed, K.
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Source Title
Journal of Infection and Chemotherapy
Print ISSN
1341321X
Electronic ISSN
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Volume
14
Issue
4
Pages
333 - 336
Language
English
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Abstract
S-carboxymethylcysteine (S-CMC) is a mucolytic agent that can prevent respiratory infection by decreasing the attachment of respiratory pathogens to human pharyngeal epithelial cells (HPECs). Streptococcus pneumoniae is a major cause of respiratory infections. A previous study revealed that treatment of S. pneumoniae with S-CMC caused a decrease in the attachment of this bacterium to HPECs. In the present study we found that the effect of S-CMC varied according to hosts and strains. S-CMC treatment altered the surface structure of S. pneumoniae, resulting in a decrease of attachment, without affecting the virulence of the bacteria. © 2008 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases.
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Keywords
Epithelial cells , Human , S-carboxymethylcysteine , Streptococcus pneumoniae , carbocisteine , penicillin G , adult , animal experiment , animal model , antibiotic resistance , article , bacterial virulence , bacterium adherence , controlled study , drug effect , electron microscopy , epithelium cell , female , human , human cell , male , minimum inhibitory concentration , mortality , mouse , nonhuman , normal human , penicillin resistance , pharynx , respiratory tract infection , Streptococcus pneumoniae , Animals , Bacterial Adhesion , Carbocysteine , Epithelial Cells , Expectorants , Female , Humans , Mice , Pharynx , Respiratory Tract Infections , Streptococcus pneumoniae