Single-neuron dynamics in human focal epilepsy
Author(s)
Truccolo, Wilson; Donoghue, Jacob Alexander; Hochberg, Leigh R.; Eskandar, Emad; Madsen, Joseph R.; Anderson, William S.; Brown, Emery N.; Halgren, Eric; Cash, Sydney S.; ... Show more Show less
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Epileptic seizures are traditionally characterized as the ultimate expression of monolithic, hypersynchronous neuronal activity arising from unbalanced runaway excitation. Here we report the first examination of spike train patterns in large ensembles of single neurons during seizures in persons with epilepsy. Contrary to the traditional view, neuronal spiking activity during seizure initiation and spread was highly heterogeneous, not hypersynchronous, suggesting complex interactions among different neuronal groups even at the spatial scale of small cortical patches. In contrast to earlier stages, seizure termination is a nearly homogenous phenomenon followed by an almost complete cessation of spiking across recorded neuronal ensembles. Notably, even neurons outside the region of seizure onset showed significant changes in activity minutes before the seizure. These findings suggest a revision of current thinking about seizure mechanisms and point to the possibility of seizure prevention based on spiking activity in neocortical neurons.
Date issued
2011-03Department
Harvard University--MIT Division of Health Sciences and Technology; Massachusetts Institute of Technology. Department of Brain and Cognitive SciencesJournal
Nature Neuroscience
Publisher
Nature Publishing Group
Citation
Truccolo, Wilson et al. “Single-neuron Dynamics in Human Focal Epilepsy.” Nature Neuroscience 14.5 (2011): 635–641.
Version: Author's final manuscript
ISSN
1097-6256
1546-1726