Metalloenzyme-like Catalyzed Isomerizations of Sugars by Lewis Acid Zeolites
Author(s)
Bermejo-Deval, Ricardo; Assary, Rajeev S.; Nikolla, Eranda; Moliner, Manuel; Roman-Leshkov, Yuriy; Hwang, Son-Jong; Palsdotter, Arna; Silverman, Dorothy; Lobo, Raul F.; Curtiss, Larry A.; Davis, Mark E.; ... Show more Show less
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Isomerization of sugars is used in a variety of industrially relevant processes and in glycolysis. Here, we show that hydrophobic zeolite beta with framework tin or titanium Lewis acid centers isomerizes sugars, e.g., glucose, via reaction pathways that are analogous to those of metalloenzymes. Specifically, experimental and theoretical investigations reveal that glucose partitions into the zeolite in the pyranose form, ring opens to the acyclic form in the presence of the Lewis acid center, isomerizes into the acyclic form of fructose, and finally ring closes to yield the furanose product. The zeolite catalysts provide processing advantages over metalloenzymes such as an ability to work at higher temperatures and in acidic conditions that allow for the isomerization reaction to be coupled with other important conversions.
Date issued
2012-06Department
Massachusetts Institute of Technology. Department of Chemical EngineeringJournal
Proceedings of the National Academy of Sciences of the United States of America
Publisher
National Academy of Sciences (U.S.)
Citation
Bermejo-Deval, R. et al. “Metalloenzyme-like Catalyzed Isomerizations of Sugars by Lewis Acid Zeolites.” Proceedings of the National Academy of Sciences 109.25 (2012): 9727–9732. Web. © 2012 National Academy of Sciences.
Version: Final published version
ISSN
1091-6490
0027-8424